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From Ion Channels to Cell-to-Cell Conversations
Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to...
Sports Investigations Law and the ECHR
This book focuses on the analysis of coercive measures that sports organisations are permitted to use as part of their internal sports investigation proceedings to investigate sports rule violations. The legality of such coercive measures is measured against the legal regime of the European Convention on Human Rights (ECHR). The book examines the important issue of the applicability of the ECHR to private sports organisations, which is currently widely debated in the field of sports law. The ECHR is hereby used as the analytical framework, which should also be a source of inspiration for jurisdictions outside the scope of application of the ECHR. The book further explores if and to what extent sports organisations and law enforcement agencies may exchange intelligence in support of both internal sports investigation proceedings and criminal investigations. At all stages, the work seeks to strike a balance between the interest of sports organisations to investigate sports rule violations and the rights of athletes and other sportspersons. The work will be an invaluable resource for students, academics and policy-makers working in the area of Sports Law and Human Rights Law.
Bibliodiversity
In a globalized world, megacorp publishing is all about numbers, sameness and following the formula of the latest megasuccess. Each book is expected to pay for itself and all the externalities of publishing. It means books that take off slowly but have long lives, books that change social norms, are less likely to be published. Encapsulated in the term bibliodiversity, coined by Chilean publishers in the 1990s, independent publishers are envisioning a different way. Susan Hawthorne provides a scathing critique of the global publishing industry, set against a visionary proposal for “organic” publishing. She looks at free speech and fair speech, at the environmental costs of mainstream publishing and at the promises and the challenges of the move to digital.
Euro-Par 2014: Parallel Processing Workshops
The two volumes LNCS 8805 and 8806 constitute the thoroughly refereed post-conference proceedings of 18 workshops held at the 20th International Conference on Parallel Computing, Euro-Par 2014, in Porto, Portugal, in August 2014. The 100 revised full papers presented were carefully reviewed and selected from 173 submissions. The volumes include papers from the following workshops: APCI&E (First Workshop on Applications of Parallel Computation in Industry and Engineering - BigDataCloud (Third Workshop on Big Data Management in Clouds) - DIHC (Second Workshop on Dependability and Interoperability in Heterogeneous Clouds) - FedICI (Second Workshop on Federative and Interoperable Cloud Infrastru...
Digital Convergence in Contemporary Newsrooms
This book explores the dynamic landscape in contemporary newsrooms across three continents by investigating the impact that the processes of searching, processing, and distributing data and information and the use of big data, with secure, automatic, and agile retrieval of information all have in this context. Journalistic organizations have undergone digital transformations, and only those implementing accurate transformations survive. In so doing, the book addresses the fields of e-Communication, Computer Science, and Information Science and other areas of the authors’ expertise. The first five chapters focus on technical visits to investigate newsrooms’ productive routines and flows i...
Hamartia
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Connexin Cell Communication Channels
Plasma membrane-associated channels known as gap junctions, along with their protein building blocks—connexins—have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in cells and tissues of the immune system. It describes their general molecular and biological char...
Hemichannels; from the molecule to the function
Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called connexins (Cxs). It is well known that GJCs are involved in several functions, such as intercellular propagation of calcium waves, spread of electrotonic potentialsand spatial buffering of ions and metabolites. On the other hand, undocked hemichannels, which are not forming GJCs, can also serve other functions as “free hemichannels”. Currently, it...
