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From Ion Channels to Cell-to-Cell Conversations
Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to...
Connexin Cell Communication Channels
Plasma membrane-associated channels known as gap junctions, along with their protein building blocks—connexins—have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in cells and tissues of the immune system. It describes their general molecular and biological char...
Hemichannels; from the molecule to the function
Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called connexins (Cxs). It is well known that GJCs are involved in several functions, such as intercellular propagation of calcium waves, spread of electrotonic potentialsand spatial buffering of ions and metabolites. On the other hand, undocked hemichannels, which are not forming GJCs, can also serve other functions as “free hemichannels”. Currently, it...
Cloud Computing and Big Data
This book constitutes the revised selected papers of the 7th International Conference on Cloud Computing and Big Data, JCC&BD 2019, held in La Plata, Buenos Aires, Argentina, in June 2019. The 12 full papers presented were carefully reviewed and selected from a total of 31 submissions. They are dealing with such topics as cloud computing and HPC; Big Data and data intelligence; mobile computing.
Cloud Computing, Big Data & Emerging Topics
This book constitutes the revised selected papers of the 10th International Conference on Cloud Computing, Big Data & Emerging Topics, JCC-BD&ET 2022, held in La Plata, Argentina*, in June-July 2022. The 9 full papers were carefully reviewed and selected from a total of 23 submissions. The papers are organized in topical sections on: Parallel and Distributed Computing; Machine and Deep Learning; Cloud and High-Performance Computing, Machine and Deep Learning, and Virtual Reality.
Co-Scheduling of HPC Applications
High-performance computing (HPC) has become an essential tool in the modern world. However, systems frequently run well below theoretical peak performance, with only 5% being reached in many cases. In addition, costly components often remain idle when not required for specific programs, as parts of the HPC systems are reserved and used exclusively for applications. A project was started in 2013, funded by the German Ministry of Education and Research (BMBF), to find ways of improving system utilization by compromising on dedicated reservations for HPC codes and applying co-scheduling of applications instead. The need was recognized for international discussion to find the best solutions to t...
Biology of Trypanosoma cruzi
Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective...
Euro-Par 2022: Parallel Processing Workshops
This book constitutes revised selected papers from the workshops held at the 28th International European Conference on Parallel and Distributed Computing, Euro-Par 2022, which took place in Glasgow, UK, in August 22–26, 2022 Out of a total of 35 submissions 24 papers have been accepted, 19 of these are included in this book. They stem from the following workshops: - Workshop on Algorithms, Models and Tools for Parallel Computing on Heterogeneous Platforms (HeteroPar)- Workshop on Asynchronous Many-Task systems for Exascale (AMTE) - Workshop on Domain Specific Languages for High-Performance Computing (DSL-HPC)- Workshop on Distributed and Heterogeneous Programming in C and C++ (DHPCC++)- Workshop on Resiliency in High Performance Computing in Clouds, Grids, and Clusters (Resilience) In addition, the proceedings also contains 6 extended abstracts from the PhD Symposium.
Biotechnology for Fuels and Chemicals
With the Twenty-Third Symposium, we sustained the tradition of providing an informal, congenial atmosphere that our participants find conducive to pursuing technical discussion of program topics. The techni cal program consisted of six sessions with 38 oral presentations, a roundtable forum, two special topic discussions and a poster session con sisting of 230 posters. A special luncheon talk on "Natural Capitalism" by Karl Rabago of the Rocky Mountain Institute was particularly enlightening. More infor mation on these provocative approaches to resources and societal needs can be found at their website, www.rmi.org. While plant biotechnology and genetically modified organisms (GMOs) for enzy...
