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Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma
  • Language: en
  • Pages: 129

Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma

Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent advances in melanoma management have focused on cell growth, proliferation, migration, and survival biomarkers. Numerous FDA-approved molecular-targeted therapies, such as tyrosine kinase inhibitors (TKIs), have been developed targeting genetic biomarkers that play a critical role in tumorigenesis when overexpressed. The use of targeted therapies as an alternative or adjuvant to immunotherapy has revolutionized the management of metastatic melanoma. Although this treatment strategy is more efficacious and less toxic than traditional therapies, targeted therapies are less effective after prolonged treatment due to acquired resistance given the mutations and activation of resistant mechanisms in melanoma tumors. In this sense, identifying novel target therapies and repositioned drugs that could modulate the disease progression, the potential molecular and pharmacological mechanisms of therapies are of utmost interest.

Ethnobotany of the Mountain Regions of Southeast Asia
  • Language: en
  • Pages: 1138

Ethnobotany of the Mountain Regions of Southeast Asia

  • Type: Book
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  • Published: 2021-06-17
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  • Publisher: Springer

This volume is a compendium of selected plant species of ethnobotanical value to the highland communities of popular Southeast Asia. “Traditional” knowledge held by local communities on their resources is always in flux and adapting to a quickly changing environment. New plants find their entry into the local pharmacopoeias, while existing ones maybe removed. Likewise, various local communities might find the same plant useful for completely different purposes. While compiling information on the species, authors have taken great care to ensure that the dynamic nature of ethnobotanical knowledge is represented adequately. Special emphasis has also been given to cultural value of species t...

DNA Repair and Cancer
  • Language: en
  • Pages: 714

DNA Repair and Cancer

  • Type: Book
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  • Published: 2013-01-22
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  • Publisher: CRC Press

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topi

Clinical Cancer Genetics
  • Language: en
  • Pages: 452

Clinical Cancer Genetics

Written by a world-recognized leader in this emerging field, Clinical Cancer Genetics provides an updated and expanded treatment of Kenneth Offit's seminal text on the clinical management associated with syndromes of cancer predisposition, with a thorough review of the relevant molecular genetics. This second edition features new coverage of pharmacogenetics, gene therapy trials, high throughput genotyping, and microarrays and includes a new focus on epigenetic events in carcinogenesis within background chapter on cancer genetics. Expanded coverage highlights more uncommon and rare cancer predisposition syndromes.

Biomedical Nanotechnology
  • Language: en
  • Pages: 170

Biomedical Nanotechnology

  • Type: Book
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  • Published: 2005-04-14
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  • Publisher: CRC Press

Biomedical nanotechnology is one of the fastest-growing fields of research across the globe. However, even the most promising technologies may never realize their full potential if public and political opinions are galvanized against them, a situation clearly evident in such controversial fields as cloning and stem cell research. Biomedical Nanotec

Project-Led Engineering Education
  • Language: en
  • Pages: 316

Project-Led Engineering Education

Are you, or is your university, satisfied with the motivation and rate of progress of students participating in the Bachelor's phase of your engineering degree program? Would you like your students to master the necessary technical skills of modern engineering, and to learn to study and to communicate effectively and efficiently? This book addresses these questions and explains how to successfully make the substantial change from a traditional teacher-led approach to a student-team-based-project-led approach to handling the Bachelor part of the engineering curriculum. The book also describes what Project-Led Engineering Education is all about and how team-based learning works.

Archivo F. X.
  • Language: en
  • Pages: 256

Archivo F. X.

  • Type: Book
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  • Published: 2015-02-28
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  • Publisher: Unknown

None

Discovering the World
  • Language: en
  • Pages: 664

Discovering the World

None

Revolutionary Multiculturalism
  • Language: en
  • Pages: 429

Revolutionary Multiculturalism

  • Type: Book
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  • Published: 2018-02-12
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  • Publisher: Routledge

This work by one of North America's leading educational theorists and cultural critics culminates a decade of social analyses that focuses on the political economy of schooling, Paulo Freire and literacy education, hip-hop culture, and multicultural education. Peter McLaren also examines the work of Baudrillard as well as Bourdieu's reflexive sociology.Always in McLaren's work is a profound understanding of the relationship among advanced capitalism, the politics of knowledge, and the formation of identity. One of the central themes of this volume is the relationship between the political and the pedagogical for educators, activists, artists, and other cultural workers. McLaren argues that the central project ahead in the struggle for social justice is not so much the politics of diversity as the global decentering and dismantling of whiteness. This volume also contains an interview with the author.

Before Pictures
  • Language: en

Before Pictures

  • Categories: Art

Front room/back room -- Spanish Harlem (East 98th Street), 1967-69 -- Way out on a nut -- Chelsea (West 23rd Street), 1969-71 -- Back to the turmoil -- West Village (West 10th Street), 1971-74 -- Art news parties -- Hotel des artistes -- Tribeca (Chambers Street), 1974-76 -- Action around the edges -- Disss-co (a fragment) -- Broadway-Nassau (Nassau Street), 1976 -- Agon -- Pictures, before and after