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Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma
Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent advances in melanoma management have focused on cell growth, proliferation, migration, and survival biomarkers. Numerous FDA-approved molecular-targeted therapies, such as tyrosine kinase inhibitors (TKIs), have been developed targeting genetic biomarkers that play a critical role in tumorigenesis when overexpressed. The use of targeted therapies as an alternative or adjuvant to immunotherapy has revolutionized the management of metastatic melanoma. Although this treatment strategy is more efficacious and less toxic than traditional therapies, targeted therapies are less effective after prolonged treatment due to acquired resistance given the mutations and activation of resistant mechanisms in melanoma tumors. In this sense, identifying novel target therapies and repositioned drugs that could modulate the disease progression, the potential molecular and pharmacological mechanisms of therapies are of utmost interest.
Nanotechnology
Nanotechnology: Advances and Real-Life Applications offers a comprehensive reference text about advanced concepts and applications in the field of nanotechnology. The text – written by researchers practicing in the field – presents a detailed discussion of key concepts including nanomaterials and their synthesis, fabrication and characterization of nanomaterials, carbon-based nanomaterials, nano-bio interface, and nanoelectronics. The applications of nanotechnology in the fields of renewable energy, medicine and agriculture are each covered in a dedicated chapter. The text will be invaluable for senior undergraduate and graduate students in the fields of electrical engineering, electronics engineering, nanotechnology and nanoscience. Dr. Cherry Bhargava is an Associate Professor and Head, VLSI domain, at the School of Electrical and Electronics Engineering of Lovely Professional University, Jalandhar, India. Dr. Amit Sachdeva is an Associate Professor at Lovely Professional University, Jalandhar, India.
Brazil in Advancing Pharmacotherapy and Clinical Pharmacy in Latin America
The Fourth Brazilian Congress of Pharmacotherapy and Clinical Pharmacy showcases Brazil's role within the vibrant and evolving community of pharmacotherapy and clinical pharmacy in Latin America. This volume offers a window into Brazil's ongoing contributions as part of a collective Latin American effort, presenting a comprehensive collection of scientific investigations and documented clinical experience reports that address important healthcare challenges. Containing hundreds of peer-reviewed works, evaluated through a double-blind review process, this publication documents ongoing progress in evidence-based, patient-centered pharmaceutical care. The compilation adheres to rigorous scientific standards, with submissions evaluated for methodological soundness, clinical relevance, and adherence to ethical guidelines. Systematically organized to facilitate knowledge transfer, this resource offers understandings into emerging therapeutic protocols, pharmacological interventions, and clinical decision-making frameworks. For researchers, clinicians, and policymakers, this publication provides an essential, data-driven foundation for advancing pharmaceutical practice in the region.
Universities, Entrepreneurial Ecosystems, and Sustainability
This volume presents theoretical and empirical research on universities and their entrepreneurial ecosystems to better grasp the connections between universities and their surrounding environments and their engagement with sustainability. The book provides a better understanding of the entrepreneurial characteristics of universities. It examines the ways in which universities’ collaboration and participation in an ecosystem support business and industry transformation. It also investigates how universities function within the university/industry/government/third sector relationship nexus. The book enables the systematisation of the literature while simultaneously builds theory, empirically testing existing theories, and contributes towards a future research agenda geared towards sustainability. The book gathers contributions from varied geographical contexts providing an international perspective.
Proceedings of the 6th Brazilian Technology Symposium (BTSym’20)
This book presents the Proceedings of The 6th Brazilian Technology Symposium (BTSym'20). The book discusses the current technological issues on Systems Engineering, Mathematics and Physical Sciences, such as the Transmission Line, Protein-Modified Mortars, Electromagnetic Properties, Clock Domains, Chebyshev Polynomials, Satellite Control Systems, Hough Transform, Watershed Transform, Blood Smear Images, Toxoplasma Gondi, Operation System Developments, MIMO Systems, Geothermal-Photovoltaic Energy Systems, Mineral Flotation Application, CMOS Techniques, Frameworks Developments, Physiological Parameters Applications, Brain–Computer Interface, Artificial Neural Networks, Computational Vision,...
Handbook of Microalgae-Based Processes and Products
The Handbook of Microalgae-based Processes and Products provides a complete overview of all aspects involved in the production and utilization of microalgae resources at commercial scale. Divided into four parts (fundamentals, microalgae-based processes, microalgae-based products, and engineering approaches applied to microalgal processes and products), the book explores the microbiology and metabolic aspects of microalgae, microalgal production systems, wastewater treatment based in microalgae, CO2 capture using microalgae, microalgae harvesting techniques, and extraction and purification of biomolecules from microalgae. It covers the largest number of microalgal products of commercial rele...
Accurate Results in the Clinical Laboratory
Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors. - Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing - Includes new case studies that highlight clinical relevance and errors to avoid - Highlights the best titles published within a variety of medical specialties - Reviewed by medical librarians and content specialists, with key selections compiled in their annual list
Operations Management for Social Good
This volume showcases the presentations and discussions delivered at the 2018 POMS International Conference in Rio. Through a collection of selected papers, it is possible to review the impact and application of operations management for social good, with contributions across a wide range of topics, including: humanitarian operations and crisis management, healthcare operations management, sustainable operations, artificial intelligence and data analytics in operations, product innovation and technology in operations management, marketing and operations management, service operations and servitization, logistics and supply chain management, resilience and risk in operations, defense, and tourism among other emerging Operations Management issues. The Production and Operations Management Society (POMS) is one of the most important and influential societies in the subject of Production Engineering and, as an international professional and academic organization, represents the interests of professionals and academics in production management and operations around the world.
Mulheres
A saúde da mulher pode passar por mudanças significativas em diferentes fases da vida, o que demanda uma assistência plena para promover a atenção integral à saúde das mulheres em todos os ciclos de vida, tendo em vista as questões de gênero, de orientação sexual, de raça/etnia e os determinantes e condicionantes sociais que impactam na saúde e na vida das mulheres. Enfatiza-se uma assistência humanizada e qualificada em todos os níveis de atenção, com ações focadas na organização do acesso aos serviços de promoção, prevenção, assistência e recuperação da saúde. Norteando essa temática, este livro está organizado em VII unidades, as quais estão divididas em 4...
