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Expectation of Clinical Decision Support Systems: a Survey Study Among Nephrologist End-users
Abstract: Background Chronic kidney disease (CKD), a major public health problem with differing disease etiologies, leads to complications, comorbidities, polypharmacy, and mortality. Monitoring disease progression and personalized treatment efforts are crucial for long-term patient outcomes. Physicians need to integrate different data levels, e.g., clinical parameters, biomarkers, and drug information, with medical knowledge. Clinical decision support systems (CDSS) can tackle these issues and improve patient management. Knowledge about the awareness and implementation of CDSS in Germany within the field of nephrology is scarce. Purpose Nephrologists' attitude towards any CDSS and potential...
Bucket Fuser: Statistical Signal Extraction for 1D 1H NMR Metabolomic Data
Abstract: Untargeted metabolomics is a promising tool for identifying novel disease biomarkers and unraveling underlying pathomechanisms. Nuclear magnetic resonance (NMR) spectroscopy is particularly suited for large-scale untargeted metabolomics studies due to its high reproducibility and cost effectiveness. Here, one-dimensional (1D) 1H NMR experiments offer good sensitivity at reasonable measurement times. Their subsequent data analysis requires sophisticated data preprocessing steps, including the extraction of NMR features corresponding to specific metabolites. We developed a novel 1D NMR feature extraction procedure, called Bucket Fuser (BF), which is based on a regularized regression ...
Memoirs Ten Years and Twenty Days
The story of the last world war, as told by Grand Admiral Karl Doenitz himself. His memoir covers his early career with submarines in the First World War and follows both his successes and failures through the Second World War, with great detail on the way the U-boat campaign was waged, as told by the man who invented U-boat tactics. Doenitz includes details of the U-boat campaigns during the Second World War as well as the opinions, ideas and commentary on the period. Of particular interest are the comments regarding British and American conduct during the war. An important social document, and an invaluable source for any student of the last war. He became the last Führer of Germany after Hitler's suicide in May 1945 and the books subtitle, Ten Years and Twenty Days, is a direct reference to the time Karl Doenitz spent in Spandau Prison having been convicted of war crimes following trial at Nuremberg.
Decisive Battles of World War II
This book is an account of the second world war from the German point of view, written by German generals who were in command at the time as well as other German military experts. Based on first-hand German sources and available Russian material.
Defeat in the East
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Donitz's Last Gamble
By the end of 1943 the German submarine war on Atlantic convoys was all but defeated, beaten by superior technology, code-breaking and air power. With losses mounting, Dönitz withdrew the wolfpacks, but in a surprise change of strategy, following the D-Day landings in June 1944, he sent his U-boats into coastal waters, closer to home, where they could harass the crucial Allied supply lines to the new European bridgehead. Caught unawares, the British and American navies struggled to cope with a novel predicament -in shallow waters submarines could lie undetectable on the bottom, and given operational freedom, they rarely needed to make signals, so neutralizing the Allied advantages of decryp...
Donitz and the Wolf Packs
On 17 September 1942 Admiral Karl Donitz, C-in-C U-boats, issued the following directive:??To all Commanders - 'All attempts to rescue members of ships sunk, therefore also fishing out swimmers and putting them into lifeboats, righting capsized lifeboats, handing out provisions and water, have to cease. Rescue contradicts the most fundamental demands of war for the annihilation of enemy ships and crews'.??This order ended what had hitherto been a war in which the opposing factions treated each other with a certain respect, seaman to seaman, showing mercy where mercy was due. It also marked the point at which the Battle of the Atlantic became a dirty war of attrition, with the U-boats hunting...
S.S. Nerissa, the Final Crossing
A remarkable human story, one that is worth reading. - Maritime Engineering Journal Fascinating story is told in a thorough and interesting manner, highly recommended. - Action Stations magazine, Canadian Naval Memorial Trust, HMCS Sackville Book is intriguing. Recommended for navy enthusiasts and more casual readers alike. - Starshell magazine, Naval Association of Canada --- Second Edition, with an Addendum. In the written histories of the Battle of the Atlantic, the S.S. Nerissa is overlooked. She was the only ship transporting Canadian Army troops to be lost to enemy action during the entire Second World War. The details of the sinking were highly classified until almost 50 years after t...
Long Night of the Tankers
On February 16th, 1942 a Nazi U-boat brazenly shelled the huge Lago oil refinery on Aruba and torpedoed the tankers Pedernales and Oranjestad, both tied up in Aruba's San Nicolas Harbour. Oranjestad was sunk and Pedernales badly damaged. The damage to the refinery was minor, but that same night other U-boats attacked and sank four more tankers in the waters between Aruba and Curaçao and Venezuela. It was the long night of the tankers and the opening salvo of a two year struggle to dominate the Caribbean Sea. In the last twelve days of February, 1942 alone the submarines sank 17 more ships, most of them tankers. Long Night of the Tankersis the story of the German effort to cut the Caribbean ...
