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Advances in Medicinal Chemistry
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
Where the Waves Fall
Where the Waves Fall (1984) centres the stories of the Pacific Islanders and how they were affected by European explorers and colonisers in this unique account of human settlement and cultural interchange in the Pacific islands. It follows the fortunes of the seafarers who discovered island after island in the world’s largest ocean, traces the development of their civilisations and examines in depth the interaction between them and the newcomers – European explorers, traders, beachcombers, missionaries, merchants – who from the sixteenth century came in an increasing series of waves. The book’s framework enables the author to throw new light on hitherto isolated events. Novel suggestions are advanced as to why some islands became ‘kingdoms’ in the earlier years of European contact and why others did not, and of how and why missionaries were accepted on some islands but not on others. Nor does Professor Howe shrink from provocative and at times controversial arguments concerning the ambitions and strategies of island leaders and indeed the overall nature and extent of the initiatives taken by the islanders.
The Quest for Origins
Did they come from space, from Egypt, from the Americas? From other ancient civilizations? These are some of today's most fanciful claims about the first settlers of the islands of the Pacific. But none of them correctly answer the question: Where did the Polynesians come from? This book is a thoughtful and devastating critique of such "new" learning, and a careful and accessible survey of modern archaeological, anthropological, genetic, and linguistics findings about the origins of Pacific Islanders. Professor Howe also examines the two-hundred-year-old history of Western ideas about Polynesian origins in the context of ever-changing fads and intellectual fashions.
Texts and Contexts
Texts and Contexts is concerned with the development of Pacific Islands history as a specialization in its own right. Specifically, this volume examines the foundational texts that pioneered and consolidated the new subdiscipline and served as the building blocks and stepping stone for further developments in the field. Thirty-five texts, all of which represent defining points in the development of Pacific Islands historiography, are examined. Much more than retrospective appraisals of the foundational texts, the individual chapters consider a text or complimentary texts within the context of the time of writing and gauge what ongoing influence they exerted. In some cases they suggest how a ...
Manual of Antibiotics and Infectious Diseases
This book covers antibiotics currently available, their doses, and their dose adjustments. It explains what to do when faced with renal failure, as well as empirical, prophylactic, and definitive antibiotic therapies--everything from bacteria resistance to AIDS therapies. (Midwest).
Medical Toxicology of Drug Abuse
This book provides a broad reference covering important drugs of abuse including amphetamines, opiates, and steroids. It also covers psychoactive plants such as caffeine, peyote, and psilocybin. It provides chemical structures, analytical methods, clinical features, and treatments of these drugs of abuse, serving as a highly useful, in-depth supplement to a general medical toxicology book. The style allows for the easy application of the contents to searchable databases and other electronic products, making this an essential resource for practitioners in medical toxicology, industrial hygiene, occupational medicine, pharmaceuticals, environmental organizations, pathology, and related fields.
Vaka Moana, Voyages of the Ancestors
"The most comprehensive and complete account yet of those ancient seafarers who developed the world's first ocean-going vessels - and the advanced navigational systems to guide them - and discovered the last habitable lands on earth, the islands of the mighty Pacific Ocean."--P. [4] of cover.
A Companion to Global Environmental History
The Companion to Global Environmental History offers multiple points of entry into the history and historiography of this dynamic and fast-growing field, to provide an essential road map to past developments, current controversies, and future developments for specialists and newcomers alike. Combines temporal, geographic, thematic and contextual approaches from prehistory to the present day Explores environmental thought and action around the world, to give readers a cultural, intellectual and political context for engagement with the environment in modern times Brings together environmental historians from around the world, including scholars from South Africa, Brazil, Germany, and China
