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Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
Did they come from space, from Egypt, from the Americas? From other ancient civilizations? These are some of today's most fanciful claims about the first settlers of the islands of the Pacific. But none of them correctly answer the question: Where did the Polynesians come from? This book is a thoughtful and devastating critique of such "new" learning, and a careful and accessible survey of modern archaeological, anthropological, genetic, and linguistics findings about the origins of Pacific Islanders. Professor Howe also examines the two-hundred-year-old history of Western ideas about Polynesian origins in the context of ever-changing fads and intellectual fashions.
Texts and Contexts is concerned with the development of Pacific Islands history as a specialization in its own right. Specifically, this volume examines the foundational texts that pioneered and consolidated the new subdiscipline and served as the building blocks and stepping stone for further developments in the field. Thirty-five texts, all of which represent defining points in the development of Pacific Islands historiography, are examined. Much more than retrospective appraisals of the foundational texts, the individual chapters consider a text or complimentary texts within the context of the time of writing and gauge what ongoing influence they exerted. In some cases they suggest how a ...
"The most comprehensive and complete account yet of those ancient seafarers who developed the world's first ocean-going vessels - and the advanced navigational systems to guide them - and discovered the last habitable lands on earth, the islands of the mighty Pacific Ocean."--P. [4] of cover.
Forty-five contributors offer information on the physical environment, history, culture, population, economy, and living environment of the Pacific islands.
This book covers antibiotics currently available, their doses, and their dose adjustments. It explains what to do when faced with renal failure, as well as empirical, prophylactic, and definitive antibiotic therapies--everything from bacteria resistance to AIDS therapies. (Midwest).
This book provides a broad reference covering important drugs of abuse including amphetamines, opiates, and steroids. It also covers psychoactive plants such as caffeine, peyote, and psilocybin. It provides chemical structures, analytical methods, clinical features, and treatments of these drugs of abuse, serving as a highly useful, in-depth supplement to a general medical toxicology book. The style allows for the easy application of the contents to searchable databases and other electronic products, making this an essential resource for practitioners in medical toxicology, industrial hygiene, occupational medicine, pharmaceuticals, environmental organizations, pathology, and related fields.
A picture says more than a thousand words. This is something that we all know to be true. Imaging has been important since the early days of medicine and bi- ogy, as seen in the anatomical studies of Leonardo Da Vinci or Andreas Vesalius. More than 100 years ago, the ?rst noninvasive imaging technologies, such as K- rad Roentgen’s X-ray technology,were applied to the medical ?eld—and while still crude—revolutionized medical diagnosis. Today, every patient will be exposed to some kind of advanced imaging technology such as medical resonance imaging, computed tomography or four-dimensional ultrasound during their lifetime. Many diseases, such as brain tumors, are initially diagnosed sole...