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European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment
The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.
Before the Holocaust
As the Nazis staged their takeover in 1933, instances of antisemitic violence began to soar. While previous historical research assumed that this violence happened much later, Hermann Beck counteracts this, drawing on sources from twenty German archives, and focussing on this early violence, and on the reaction of German institutions and the elites who led them. Before the Holocaust examines the antisemitic violence experienced in this period - from boycotts, violent attacks, robbery, extortion, abductions, and humiliating 'pillory marches', to grievous bodily harm and murder - which has hitherto not been adequately recognized. Beck then analyses the reactions of those institutions that stil...
The human intestinal bacterium Eggerthella lenta influences gut metabolomes in gnotobiotic mice
The intestinal microbiota and its metabolites are known to influence host metabolic health. However, little is known about the role of specific microbes. In this work, we used the minimal consortium Oligo-Mouse-Microbiota (OMM12) to study the function of Coriobacteriia under defined conditions in gnotobiotic mice. OMM12 mice with or without the addition of the dominant gut bacterium Eggerthella lenta (E. lenta) were fed with diets varying in fat content and primary bile acids. E. lenta stably colonised the mouse caecum at high relative abundances (median: 27.5%). This was accompanied by decreased occurrence of Akkermansia muciniphila and Enterococcus faecalis, but results did not reach stati...
To Improve Health and Health Care
Since 1972, the Robert Wood Johnson Foundation has been the nation's largest philanthropy devoted exclusively to health. To further its mission of improving the health and health care of all Americans, the Foundation strives to foster innovation, develop ideas, disseminate information, and enable committed people to devote their energies to improving the nation's well-being. As part of the Foundation's efforts to inform the public, To Improve Health and Health Care, the ninth volume in the Robert Wood Johnson Foundation Anthology series, provides an in-depth look into the programs it funds. Written for policymakers and practitioners, as well as interested members of the public, the series offers valuable lessons for leaders and educators developing plans for the coming years.
Preventing Violence Against Women and Children
Violence against women and children is a serious public health concern, with costs at multiple levels of society. Although violence is a threat to everyone, women and children are particularly susceptible to victimization because they often have fewer rights or lack appropriate means of protection. In some societies certain types of violence are deemed socially or legally acceptable, thereby contributing further to the risk to women and children. In the past decade research has documented the growing magnitude of such violence, but gaps in the data still remain. Victims of violence of any type fear stigmatization or societal condemnation and thus often hesitate to report crimes. The issue is...
The Flexible Phenotype
In essence, the authors argue for the existence of direct, measurable, links between phenotype and ecology.
Communications and Technology for Violence Prevention
In the last 25 years, a major shift has occurred in the field of violence prevention, from the assumption that violence is inevitable to the realization that violence is preventable. As we learn more about what works to reduce violence, the challenge facing those who work in the field is how to use all of this new information to rapidly deploy or enhance new programs. At the same time, new communications technologies and distribution channels have altered traditional means of communications, and have made community-based efforts to prevent violence possible by making information readily available. How can these new technologies be successfully applied to the field of violence prevention? On ...
Knowledge to Action
AN ESSENTIAL CONVERSATION FROM TODAY'S LEADING VOICES ON EFFECTING CHANGE IN HEALTH AND SOCIETY "The Robert Wood Johnson Foundation has changed the conversation about health in the United States." --Jo Ivey Boufford, President, New York Academy of Medicine In a society where a person's zip code is a stronger predictor of health status than their genetic profile, every public health challenge is also a challenge of equity, implementation, and policy. For better or worse, improving health requires societal change, and the scale of today's societal challenges can have a stifling effect on even the most well-intended efforts. Assembled by the Robert Wood Johnson Foundation and featuring today's ...
Contagion of Violence
The past 25 years have seen a major paradigm shift in the field of violence prevention, from the assumption that violence is inevitable to the recognition that violence is preventable. Part of this shift has occurred in thinking about why violence occurs, and where intervention points might lie. In exploring the occurrence of violence, researchers have recognized the tendency for violent acts to cluster, to spread from place to place, and to mutate from one type to another. Furthermore, violent acts are often preceded or followed by other violent acts. In the field of public health, such a process has also been seen in the infectious disease model, in which an agent or vector initiates a spe...
Social and Economic Costs of Violence
Measuring the social and economic costs of violence can be difficult, and most estimates only consider direct economic effects, such as productivity loss or the use of health care services. Communities and societies feel the effects of violence through loss of social cohesion, financial divestment, and the increased burden on the healthcare and justice systems. Initial estimates show that early violence prevention intervention has economic benefits. The IOM Forum on Global Violence Prevention held a workshop to examine the successes and challenges of calculating direct and indirect costs of violence, as well as the potential cost-effectiveness of intervention.
