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The PNUTS-PP1 Axis Regulates Endothelial Aging and Barrier Function Via SEMA3B Suppression
Age-related diseases pose great challenges to health care systems worldwide. During aging, endothelial senescence increases the risk for cardiovascular disease. Recently, it was described that Phosphatase 1 Nuclear Targeting Subunit (PNUTS) has a central role in cardiomyocyte aging and homeostasis. Here, we determined the role of PNUTS in endothelial cell aging. We confirmed that PNUTS is repressed in senescent endothelial cells (ECs). Moreover, PNUTS silencing elicits several of the hallmarks of endothelial aging: senescence, reduced angiogenesis and loss of barrier function. To validate our findings in vivo, we generated an endothelial-specific inducible PNUTS-deficient mouse line (Cdh5-Cr...
A Brief History of Blood and Lymphatic Vessels
This book provides a comprehensive account of vascular biology and pathology and its significance for health and disease. It systematically and chronologically explains how we came to our current understanding of the vasculature and it ́s function today, and describes in an entertaining way the diverse flaws and turns in science and medicine from the past. It thereby offers a complete and well-studied history on vascular biology and medicine. The book has an easy-to-read style and is written for students as well as scientists, physicians and lecturers in the field of biomedicine, human physiology, cardiology and hematology.
Web Design in easy steps, 6th edition
There are literally millions of websites on the Internet, but most are ugly and ineffective. So how do you create a site that looks good and makes money? Web Design in easy steps, now in its sixth edition, reveals the key principles of good web design. It guides you through the process of creating a website, from planning to search engine promotion. Learn: The fundamentals of professional web page layout and create content that’ll get your message across.All about effective navigation to make your website easy to use so your visitors stay longer.The techniques to make your website attractive for all and ensure it works on different devices.How to use HTML, CSS and JavaScript and get started with your new website.Ecommerce and social media basics to open your online shop, and start marketing it! Avoid creating another ineffective website on the net. Use Web Design in easy steps to create a successful site that looks good and achieves its purpose.
Realty and Building
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Stanford
Migdol has included easy-to-read stories about legendary football coaches Pop Warner and Bill Walsh; the exploits of the Vow Boys, the Thunderchickens, and the Immortal 21; basketball great Hank Luisetti; golfing phenom Tiger Woods; the world's greatest athlete, Ernie Nevers; Heisman Trophy winner Jim Plunkett; the thrills generated by such Olympic champions as Bob Mathias, Pablo Morales, and Janet Evans; and the unforgettable moments made possible by such Cardinal greats as John Elway, Jennifer Azzi, Kim Oden, Paul Carey, Frankie Albert, and many more. Also included is a listing of Stanford University letter winners and Olympic champions.
On the Move to Meaningful Internet Systems: OTM 2013 Workshops
This volume constitutes the refereed proceedings of the international workshops, Confederated International Workshops: OTM Academy, OTM Industry Case Studies Program, ACM, EI2N, ISDE, META4eS, ORM, SeDeS, SINCOM, SMS and SOMOCO 2013, held as part of OTM 2013 in Graz, Austria, in September 2013. The 75 revised full papers presented together with 12 posters and 5 keynotes were carefully reviewed and selected from a total of 131 submissions. The papers are organized in topical sections on: On The Move Academy; Industry Case Studies Program; Adaptive Case Management and other non-workflow approaches to BPM; Enterprise Integration, Interoperability and Networking; Information Systems in Distributed Environment; Methods, Evaluation, Tools and Applications for the Creation and Consumption of Structured Data for the e-Society; Fact-Oriented Modeling; Semantics and Decision Making; Social Media Semantics; Social and Mobile Computing for collaborative environments; cooperative information systems; Ontologies, Data Bases and Applications of Semantics.
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