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Analysis of RAS and Drug Induced Homo- and Heterodimerization of RAF and KSR1 Proteins in Living Cells Using Split Nanoluc Luciferase
Abstract: The dimerization of RAF kinases represents a key event in their activation cycle and in RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key insights into this process defining RAF signaling output and the clinical efficacy of RAF inhibitors (RAFi). However, methods reporting the dynamics of RAF dimerization in living cells and in real time are still in their infancy. Recently, split luciferase systems have been developed for the detection of protein-protein-interactions (PPIs), incl. proof-of-concept studies demonstrating the heterodimerization of the BRAF and RAF1 isoforms. Due to their small size, the Nanoluc luciferase moieties LgBiT and SmBiT...
Annual Report of the Commissioner of Patents
Prior to 1862, when the Department of Agriculture was established, the report on agriculture was prepared and published by the Commissioner of Patents, and forms volume or part of volume, of his annual reports, the first being that of 1840. Cf. Checklist of public documents ... Washington, 1895, p. 148.
Modern Printmaking
A fully illustrated instructional printmaking book presenting step-by-step examples alongside representative works from thirty top contemporary printmaking artists. Printmaking is flourishing in the modern era, appealing to both traditional artists as well as those interested in graphic design and digital techniques. This all-in-one guide is both technical and inspirational, examining the history and contemporary processes of relief, intaglio, lithography, serigraphy, mixed media, digital transfers, and post-digital graphics. Featuring step-by-step examples alongside representative works and profiles of top printmaking artists, this colorful resource provides a truly fresh look at printmaking today, in all its forms.
Bulletin
Vol. 12 includes under the same cover the society's year-book for 1912.
House documents
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Symposium on Rosin
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