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AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Analysis of RAS and Drug Induced Homo- and Heterodimerization of RAF and KSR1 Proteins in Living Cells Using Split Nanoluc Luciferase
Abstract: The dimerization of RAF kinases represents a key event in their activation cycle and in RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key insights into this process defining RAF signaling output and the clinical efficacy of RAF inhibitors (RAFi). However, methods reporting the dynamics of RAF dimerization in living cells and in real time are still in their infancy. Recently, split luciferase systems have been developed for the detection of protein-protein-interactions (PPIs), incl. proof-of-concept studies demonstrating the heterodimerization of the BRAF and RAF1 isoforms. Due to their small size, the Nanoluc luciferase moieties LgBiT and SmBiT...
Exometabolom Analysis of Breast Cancer Cell Lines: Metabolic Signature
Abstract: Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of different subtypes of breast cancer cell lines and the breast epithelial cell line MCF-10A. Prepurification of cell culture supernatants was performed by cis-diol specific affinity chromatography using boronate-derivatized polyacrylamide gel. Samples were analyzed by application of reversed phase chromatography coupled to a triple quadrupole mass spectrometer. Collectively, we determined 23 compounds from RNA metabolism, two from purine metabolism, five from polyamine/methionine cycle, one fro...
Giving a voice to the Oppressed?
Due to its internationality and interdisciplinarity, the International Oral History Association (IOHA), which was founded in the late 1970's, is one-of-a-kind in the academic landscape. Driven by the desire to democratize historical scholarship, its members wanted to "give a voice" to groups such as women, workers, migrants, or victims of political dictatorships who had not been heard up to that point. The contributions deal with the academic approaches and the political convictions of the previous generation.
