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The Family of Ronald W. Reagan
Ronald Wilson Reagan was born 6 Feb 1911 in Tampico, Illinois, to John Edward Reagan and Nellie Wilson. He married first Jane Wyman (nee Sarah Jane Fulks), daughter of Richard D. Fulks and Emma Reise, 24 Jan 1940 in Glendale, California. He married Nancy Davis (nee Anne Frances Robbins), daughter of Kenneth Robbins and Edith Luckett, 4 Mar 1952 in North Hollywood, California. Ancestors and relatives lived mainly in Scotland and Illinois.
Song of Freedom, Song of Dreams
From award-winning verse novelist Shari Green comes an unforgettable story of friendship, first love, and an impossible choice between integrity and duty, family and friends, all while fighting for a dream. Song of Freedom, Song of Dreams is a historical YA novel in verse that centers around a young pianist in East Germany trying to make sense of love, duty, and the pursuit of dreams during the unsettled months of protest that led to the fall of the Berlin Wall in the late 1980s. Written in stunning lyrical verse, Song of Freedom, Song of Dreams is a story of hope, courage, romance, and the power of music not only to change lives, but to save them.
Michael Schumacher
Michael Schumacher werd een sportlegende dankzij een zeldzame combinatie van extreme professionaliteit en koelbloedigheid. Zijn tegenstanders vreesden de nietsontziende, vastbesloten coureur die alles deed om zijn doelen te bereiken. Zijn tragische ski-ongeval in december 2013 schokte de hele wereld. Wat een bittere ironie: een zevenvoudig wereldkampioen die zijn hele carrière nauwelijks noemenswaardig letsel oploopt, en dan tijdens een familie-uitje in de Franse Alpen zo zwaar ten val komt. Thuis was hij de liefhebbende echtgenoot en vader, op het circuit stond hij bekend als 'race-robot' - koel, perfect, onaantastbaar, altijd 'in control'. De gerenommeerde sportjournaliste Karin Sturm is dé Schumacher-kenner bij uitstek. Ze maakt al dertig jaar deel uit van de Formule 1-wereld en kent Schumacher vanaf het begin van zijn loopbaan. Sturm maakt in deze biografie bewust ruimte voor de mens achter de wereldkampioen en schetst zo een compleet beeld van de beste Formule 1-coureur aller tijden.
Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT
Abstract: The spore-forming gut bacterium Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitalized patients. The major virulence factors are two large glucosylating cytotoxins. Hypervirulent strains (e.g. ribotype 027) with higher morbidity and mortality additionally produce the binary CDT toxin (Clostridium difficile transferase) that ADP-ribosylates actin and induces microtubule-based cell protrusions. Nanobodies are robust single domain antibodies derived from camelid heavy chain antibodies. Here we report the generation of functional nanobodies against the enzymatic CDTa and the heptameric receptor binding subunit CDTb. The nanobodies were obtained from a variable-domain repertoire library isolated from llamas immunized with recombinant CDTa or CDTb. Five CDTa-specific nanobodies blocked CDTa-mediated ADP-ribosylation of actin. Three CDTa-specific and two CDTb-specific nanobodies neutralized the cytotoxicity of CDTa+b. These nanobodies hold promise as new tools for research, diagnosis and therapy of C. difficile associated disease
Michael Schumacher
C’è la forza di una tragedia greca, nella vita di Michael Schumacher. Il campione dei campioni del volante, imbattibile, indistruttibile. Semplicemente il migliore, in tutto. Sette titoli mondiali, 91 successi, 68 pole position. Record imbattuti: chissà se ci sarà mai qualcuno che riuscirà nell’impresa di superarli. Difficile, molto difficile. A Imola, il 1° maggio 1994, nel giorno più nero, è testimone diretto dello schianto della Williams di Senna contro il muro della curva del Tamburello. Nel 1996 viene chiamato alla Ferrari da Luca Montezemolo e Jean Todt, come un salvatore. Un avvio difficile, talvolta disastroso, con macchine che perdono i pezzi. Poi l’attacco ai piani alt...
Michael Schumacher
Michael Schumacher -- the most successful Grand Prix driver of all time -- remained a quiet-spoken, private family man throughout his controversial career. The global celebrity was a global stranger. This is his full story, from humble beginnings to fashioning Ferrari in his own image, from a homemade kart to his very last race in China in October 2006 and the thrilling battle for the eighth World Championship.
