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Brain Damage and Repair
Brain Damage and Repair aims to attract the interest of neuroscientists and clinical neurologists by building a novel bridge from molecular research to clinical therapy. This novel approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration. Comprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowledge, apply it at the clinical level to provide a basis for novel therapeutic strategies. Brain Damage and Repair is completed with chapters on imaging techniques, viral gene transfer or legal international handling of stem cell transfer and patents of DNA/proteins.
The English Master of Arms
First published in 1956, The English Master of Arms presents a fascinating chapter of social history, not merely of fencing. It was the common custom of gentlemen to bear arms, and the background to this custom is an important aspect of history of manners and conduct. Changes in social condition made the weapon an accessory to dress rather than a protective equipment; but the enthusiasm for the cult of arms increased. Amply encouraged, the Master of Arms brought his art ever nearer to perfection; at the same time, he became a recognised arbiter of conduct, for he insisted upon the exact observance of a strict code of honour, of courtesy, and of self-restraint. Essentially unassuming, he relied for his social influence upon his own example, and he seemed to his contemporaries such an unchanging unit in the established order of life that it did not occur to them to hand down their impressions to succeeding generations. This book is an effort to remedy their omission by recording from widely scattered sources the simple annals of the English Master of Arms, of how he emerged, established his schools, and taught his art.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Tropics of Haiti
A literary history of the Haitian Revolution that explores how scientific ideas about ‘race’ affected 19th-century understandings of the Haitian Revolution and, conversely, how understandings of the Haitian Revolution affected 19th-century scientific ideas about race.
SEC Docket
None
The Investors Review
None
The Biology of Subcellular Nitric Oxide
This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.
Gene and Cell Therapy: Biology and Applications
Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.
