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Cytokine Storm Syndrome
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
Metal-Organic Frameworks
Focusing on applications in separation, adsorption and catalysis, this handbook underlines the importance of this hot and exciting topic. It provides an excellent insight into the synthesis and modification of MOFs, their synthesis on an industrial scale, their use as CO2 and chemical warfare adsorbers, and the role of defects in catalysis. In addition, the authors treat such new aspects as biocatalysis and applications in photocatalysis and optoelectronic devices.
Elements of Information Theory
The latest edition of this classic is updated with new problem sets and material The Second Edition of this fundamental textbook maintains the book's tradition of clear, thought-provoking instruction. Readers are provided once again with an instructive mix of mathematics, physics, statistics, and information theory. All the essential topics in information theory are covered in detail, including entropy, data compression, channel capacity, rate distortion, network information theory, and hypothesis testing. The authors provide readers with a solid understanding of the underlying theory and applications. Problem sets and a telegraphic summary at the end of each chapter further assist readers. The historical notes that follow each chapter recap the main points. The Second Edition features: * Chapters reorganized to improve teaching * 200 new problems * New material on source coding, portfolio theory, and feedback capacity * Updated references Now current and enhanced, the Second Edition of Elements of Information Theory remains the ideal textbook for upper-level undergraduate and graduate courses in electrical engineering, statistics, and telecommunications.
Understanding Gender and Organizations
`An unusually comprehensive and sophisticated analysis of how organizations and the men and women who work within them are affected by gendered processes and relations. Alvesson and Billing′s contribution is unique in its sensitivity to the wide range of processes affected by gender paired with its sensitivity to the pitfalls of inappropriately applying a gender lens. This book is a must-read for organizational researchers and gender scholars′ - Debra Meyerson, Stanford University `Students and scholars alike will find this at once a useful overview and a thought-provoking take on the complexity of gender-in-organizations and gendered organizations′ - Robin J. Ely, Warren Alpert Profes...
Cellular Ceramics
Cellular ceramics are a specific class of porous materials which includes among others foams, honeycombs, connected fibers, robocast structures and assembled hollow spheres. Because of their particular structure, cellular ceramics display a wide variety of specific properties which make them indispensable for various engineering applications. An increasing number of patents, scientific literature and international conferences devoted to cellular materials testifies to a rapidly growing interest of the technical community in this topic. New applications for cellular ceramics are constantly being put under development. The book, authored by leading experts in this emerging field, gives an overview of the main aspects related to the processing of diverse cellular ceramic structures, methods of structural and properties characterisation and well established industrial, novel and potential applications. It is an introduction to newcomers in this research area and allows students to obtain an in-depth knowledge of basic and practical aspects of this fascinating class of advanced materials.
Price-Based Investment Strategies
This compelling book examines the price-based revolution in investing, showing how research over recent decades has reinvented technical analysis. The authors discuss the major groups of price-based strategies, considering their theoretical motivation, individual and combined implementation, and back-tested results when applied to investment across country stock markets. Containing a comprehensive sample of performance data, taken from 24 major developed markets around the world and ranging over the last 25 years, the authors construct practical portfolios and display their performance—ensuring the book is not only academically rigorous, but practically applicable too. This is a highly useful volume that will be of relevance to researchers and students working in the field of price-based investing, as well as individual investors, fund pickers, market analysts, fund managers, pension fund consultants, hedge fund portfolio managers, endowment chief investment officers, futures traders, and family office investors.
Organizational Behavior, Theory, and Design in Health Care
Organizational Behavior, Theory, and Design, Third Edition was written to provide health services administration students, managers, and other professionals with an in-depth analysis of the theories and concepts of organizational behavior and organization theory while embracing the uniqueness and complexity of the healthcare industry. Using an applied focus, this book provides a clear and concise overview of the essential topics in organizational behavior and organization theory from the healthcare manager’s perspective. The Third Edition offers: - New case studies throughout underscore key theories and concepts and illustrate practical application in the current health delivery environment - In-depth discussion of the industry’s redesign of health services offers a major focus on patient safety and quality, centeredness, and consumerism. - Current examples reflect changes in the environment due to health reform initiatives. - And more.
Inefficient Markets
The efficient markets hypothesis has been the central proposition in finance for nearly thirty years. It states that securities prices in financial markets must equal fundamental values, either because all investors are rational or because arbitrage eliminates pricing anomalies. This book describes an alternative approach to the study of financial markets: behavioral finance. This approach starts with an observation that the assumptions of investor rationality and perfect arbitrage are overwhelmingly contradicted by both psychological and institutional evidence. In actual financial markets, less than fully rational investors trade against arbitrageurs whose resources are limited by risk aver...
Construction and utilization of digital twins for personalized therapeutic predictions
Modern healthcare faces a significant challenge, namely that 25-70% of patients with common diseases do not benefit from standard treatments despite the availability of over 13,000 drugs registered in DrugBank. This discrepancy is likely due to these diseases' complex and heterogeneous molecular nature rather than a lack of therapeutic options. Emerging technologies have revealed the immense molecular complexity underlying common diseases. For instance, singlecell RNA sequencing (scRNA-seq) has demonstrated altered gene interactions in and across multiple cell types in numerous tissues. Furthermore, these technologies have revealed vast molecular differences between patients with the same di...
