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Gynecologic Oncology
More often than not, progress in medicine occurs incrementally. The report of an 'important' new observation is typically greeted by a mixture of excitement and skepticism. Yet the true value of the discovery may not be known for several years until it is confirmed (or refuted) by independently conducted studies. In some cases, controversy may continue to shroud a topic due to the discordant results generated by different research groups. Since the last Gynecologic Oncology volume in the Cancer Treatment and Research series, a number of new areas have emerged that shed new light on the pathogenesis, diagnosis, and treatment of gynecologic malignancies. In this volume of the Cancer Treatment ...
Colorectal Cancer
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The Camptothecins
The proceedings of the first major symposium on campothecins, this volume highlights the importance of campothecins as chemotherapeutic agents and emphasizes the use of the xenograft model in research in chemotherapeutics. The xenograft model has been shown to be important both for assessing how human tumors grow in vivo and for providing an experimental system for testing new chemotherapeutic agents. This volume covers all aspects of this promising class of anticancer agents - from basic science to clinical use - and should be of interest to a wide range of research scientists and clinicians.
The Drug Development Paradigm in Oncology
Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, th...
The Biotech Business Handbook
One comment often repeated to me by coworkers in the biotechnology industry deals with their frustration at not understanding how their particular roles fit into their company's overall scheme for developing, manufacturing, and marketing biomedical products. Although these workers know their fields of specialty and responsibilities very well, whether it be in product research and development, regulatory affairs, manufacturing, packaging, quality control, or marketing and sales, they for the most part lack an understanding of precisely how their own contributory pieces fit into the overall scheme of the corporate biotechnology puzzle. The Biotech Business Handbook was written to assist the bi...
Ovarian Cancer
This reference details recent knowledge of ovarian cancer. Areas covered include: the genetic basis and molecular biology of ovarian cancer, analytic approaches to diagnosis and management, experimental therapeutics - gene therapy, methodology for dose intensification, new drugs, and quality of life and ethical issues.
