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The Camptothecins
The impact of camptothecin and its derivatives on topoiomerase I in studies on nude mice points to anticancer potential that has not yet been fully realized and developed. The 1996 Academy conference research on the camptothecins launched major advances in understanding camptothecin's mechanism of action; the development of new derivatives; and to a second generation of camptothecin-based chemotherapies. These proceedings papers unfold this potential in four areas: mechanisms of action for the natural compound and current derivatives; chemical possibilities of modifying camptothecin; novel derivatives; and novel routes of administration that enhance camptothecin's lactone ring stability, which appears vitally important for maintaining anticancer activity in humans. The science of camptothecin-base anticancer is balanced by clinical and pharmacology topics including drug resistance, new analogs and potential therapies for premature asthma and for bone marrow.
The Camptothecins
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Handbook of Nanotechnology in Nutraceuticals
Nanotechnology has been emerging as an important tool in the nutraceutical and food industries to improve the overall quality of life. Nanotechnology has established a new horizon by bestowing modified properties on nanomaterials and applying them to the production of nanoformulations, nutritional supplements, and the food industry. The Handbook of Nanotechnology in Nutraceuticals highlights the impact of nanotechnology on the food industries. The book focuses on the application of nanotechnology in nutraceuticals and the food industry to improve the overall quality of life. The book also addresses some important applications of nano-nutraceuticals in the treatment of different diseases, suc...
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Camptothecins New Anticancer Agents
This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigger a cascade of events leading to programmed cell death. Special attention is given to the adverse effects of camptothecin treatment, as well as to prevention and control. The book boasts contributions by some of the most respected authorities in camptothecin research, who have Conducted much of the pre-clinical work which helped to renew interest in camptothecins Discovered and identified the natural product camptothecin and synthesized most of the anlogues Discovered the mechanism of camptothecin cytotoxicity
