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Sulfur-Containing Marine Bioactives
Sulfur is an essential element for all living organisms and is required by algae, plants, fungi, animals, and humans for growth and development. It is present in a variety of biomolecules involved in many biological functions, including the maintenance of cell redox homeostasis, defense, and detoxifying processes. The alteration of sulfur compound metabolism may lead to human diseases as well as to plant and animal pathologies. The marine environment, which is characterized by a high biodiversity of species and a great chemical diversity, represents a great potential source of bioactive sulfur molecules. A broad range of biologically active sulfur compounds with unique structures and pharmacological properties have been reported to occur in marine organisms, from amino acids to different sulfated derivatives. Great attention is also focused on sulfur metabolites in the marine microbial world in relation to the global sulfur cycle. The aim of this Special Issue is to present existing knowledge and recent studies on sulfur-containing marine bioactive compounds in different biological systems. Attention is also focused on metabolites active at the ecological level.
Anticancer Agents
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, ...
Bioactive Compounds from Marine-Derived Aspergillus, Penicillium, Talaromyces and Trichoderma Species
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Alternative and Novel Livestock Feed: Reducing Environmental Impact
Livestock production systems are generally considered to have various negative environmental impacts, including nutrient leaching, and a significant contribution to global warming. In this respect, the reduction of gas or ammonia emissions can be achieved through improved efficiency in the choice of feedstuffs. The use of alternative feeds or additives can contribute to a more energy-efficient ration with lower emissions. Such strategies can contribute to improved animal production and health status. Studies have reported that feed additives such as nitrogen-containing compounds, probiotics, prebiotics, and plant extracts significantly reduce ruminant methane. Moreover, research suggested that fruit pomaces could be a low-cost fibre source in poultry nutrition, and that the inclusion of orange pulp in pigs’ diets can reduce the potential ammonia and methane emissions. To properly evaluate the most adequate reuse strategy it is necessary a specific life cycle assessment for each co-product.
Advances in Bioinformatics
The fields of Bioinformatics and Computational Biology have been growing steadily over the last few years boosted by an increasing need for computational techniques that can efficiently handle the huge amounts of data produced by the new experimental techniques in Biology. This calls for new algorithms and - proaches from fields such as Data Integration, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Also, new global approaches, such as Systems Biology, have been emerging replacing the reductionist view that dominated biological research in the last d- ades. Indeed, Biology is more and more a science of information needing tools from th...
Drug Design with an Ethnobotanical Concept, Volume 1
This handbook comprises huge data amounts considering the areas of world-wide Ethnopharmacology, Pharmacognosy together with modern identification tools within Phytochemistry. In recent years, modern drug design has its return back to nature, rather applying guidance achieved from herb remedies valid during centuries. The handbook established on information of 100 medicinal plants from all parts of the globe, encloses now over 4700 chemical components, their structural formulas and so far, over 500 identification spectra (EI-MS 85%, NMR 15%). It facilitates the rapid survey on medicinal plants as well as search for remedies, where the possibility exists in searching at Portuguese and Russian...
Chemical Abstracts
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Chemistry of Love and Sex
Chemistry of Love and Sex is a chemist's guide to the chemical phenomena and molecules associated with endogenous hormonal mechanisms and brain neurotransmission - the basis of many emotions associated with love, passion, and sex. Chemistry of Love and Sex demonstrates how these substances interact and "play" with each other in the different phases of human relationships. External factors which may influence love and sex, such as pharmaceuticals, cosmetics or food are also considered.
