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Monoclonal Antibodies
  • Language: en
  • Pages: 472

Monoclonal Antibodies

This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.

Chronic Lymphocytic Leukemia Research Focus
  • Language: en
  • Pages: 246

Chronic Lymphocytic Leukemia Research Focus

Chronic lymphocytic leukaemia (or "chronic lymphoid leukaemia"), known for short as CLL, is a type of leukaemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukaemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age. Over 75% of new cases are diagnosed in patients over age 50. This book presents important research from around the world in this field.

Management of Hematologic Malignancies
  • Language: en
  • Pages: 527

Management of Hematologic Malignancies

Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology.

Molecular Biomethods Handbook
  • Language: en
  • Pages: 1105

Molecular Biomethods Handbook

Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. This book expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Written by a well-established panel of research scientists, the book provides an up-to-date collection of methods used regularly in the authors’ own research programs.

Mass Spectrometry Data Analysis in Proteomics
  • Language: en
  • Pages: 322

Mass Spectrometry Data Analysis in Proteomics

This is an in-depth guide to the theory and practice of analyzing raw mass spectrometry (MS) data in proteomics. The volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. General guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided, with specific attention to identifying poor quality data and optimizing search parameters.

Metabolomics
  • Language: en
  • Pages: 290

Metabolomics

Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.

Hematologic Malignancies: Acute Leukemias
  • Language: en
  • Pages: 302

Hematologic Malignancies: Acute Leukemias

Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Precision Pathology of Cancer
  • Language: en
  • Pages: 243

Precision Pathology of Cancer

  • Type: Book
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  • Published: 2024-11-05
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  • Publisher: CRC Press

Precision pathology of cancer is a new frontier - a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer. Covers both the conceptual bases and the clinical applications Enables pathologists, haematologists, and medical oncologists to apply Precision Pathology to their daily clinical practice Covers the whole range of cancers in practical detail

Microarrays
  • Language: en
  • Pages: 923

Microarrays

Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments. Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probe...

Topics in Anti-Cancer Research
  • Language: en
  • Pages: 668

Topics in Anti-Cancer Research

This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery. The comprehensive range of themes covered in this third volume will be of benefit to clinicians, scientists and R&D experts looking for new targets for the prevention of cancer and discovery of drugs for the treatment of different cancer types. Regulation of tumor cells by TRAIL receptors, development of anti- cancer drugs & immunomodulatory drugs, molecular studies of adrenocortical cancer, role of inhibitors of inosine monophosphate dehydrogenase i...