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A concise introductory textbook on the development of the nervous system This textbook offers a concise introduction to the exciting field of developmental neuroscience, a discipline concerned with the mechanisms by which complex nervous systems emerge during embryonic growth. Bridging the divide between basic and clinical research, it captures the extraordinary progress that has been achieved in the field. It provides an opportunity for students to apply and extend what they have learned in their introductory biology courses while also directing them to the primary literature. This accessible textbook is unique in that it takes an in-depth look at a small number of key model systems and sig...
Reproducibility is fundamental to the scientific method. After reading a paper describing research findings, a scientist should be able to repeat the experiment and obtain the same results. Yet an alarming number—perhaps as high as 90 percent—of published biomedical research papers face challenges in independent replication. Such issues range from honest mistakes to outright fraud. The scope of this crisis, however, underscores deeper systemic issues within the scientific community: its culture, incentives, and institutions. In Unreliable, the distinguished scientist Csaba Szabo examines the causes and consequences of the reproducibility crisis in biomedical research, showing why the fac...
Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing
"In this book, Peter Robin Hiesinger explores historical and contemporary attempts to understand the information needed to make biological and artificial neural networks. Developmental neurobiologists and computer scientists with an interest in artificial intelligence - driven by the promise and resources of biomedical research on the one hand, and by the promise and advances of computer technology on the other - are trying to understand the fundamental principles that guide the generation of an intelligent system. Yet, though researchers in these disciplines share a common interest, their perspectives and approaches are often quite different. The book makes the case that "the information pr...
“Demonstrates how some of the most accomplished and elite scientific gatekeepers may have lied, cheated, squandered trust and endangered lives.” —The Wall Street Journal For readers of Empire of Pain and Dopesick, an arresting deep dive into how Alzheimer’s disease treatment has been set back by corrupt researchers, negligent regulators, and the profit motives of Big Pharma. Nearly seven million Americans live with Alzheimer’s disease, a tragedy that is already projected to grow into a $1 trillion crisis by 2050. While families suffer and promises of pharmaceutical breakthroughs keep coming up short, investigative journalist Charles Piller’s Doctored shows that we’ve quite like...
Books on both chicken immunology and developmental biology are rare. This one, however, summarizes all aspects of both areas and therefore represents a valuable compendium for experienced researchers as well as for all newcomers to the field. Following a lengthy discussion of the origin of hemopoietic cells, regulatory elements for the differentiation of these cells and B and T cell lymphopoiesis, the book goes on to describe the generation of transgenic chickens as well as an additional basic feature in embryogenesis: the positioning of organ anlage, e.g. the limb bud. To round off, a valuable compilation of monoclonal antibodies further enhances the practical usefulness of this important book.
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
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"This book mounts a defense of academic freedom by probing its role in multiple contexts, thereby offering readers an introduction to and exploration of the concept. It strives to elucidate the term's sometimes complicated meanings and uses for faculty members, administrators, trustees, journalists, politicians, and anyone with an interest in higher education's future"--
Karp’s Cell and Molecular Biology delivers a concise and illustrative narrative that helps students connect key concepts and experimentation, so they better understand how we know what we know in the world of cell biology. This classic text explores core concepts in considerable depth, often adding experimental detail. It is written in an inviting style and at mid-length, to assist students in managing the plethora of details encountered in the Cell Biology course. The 9th Edition includes two new sections and associated assessment in each chapter that show the relevance of key cell biology concepts to plant cell biology and bioengineering.