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Gene Therapy for Neurological Disorders
Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.
Transgenic Models in Endocrinology
The dramatic recent expansion in genomic information has motivated the development of new approaches to characterize gene expression and function. A critical issue for both basic and clinical endocrinologists is the physiological role of genes involved in regulating endocrine functions. Transgenic technologies allow the translation of genotypic information into specific phenotypes by using gene overexpression or loss of specific gene functions. Murine functional genomics is thus of central importance in modem biomedical endocrine research. Although mice are at present, the preferred mammalian species for genetic manipulations because of the availability of pluripotent embryonic. stem cells a...
The Spy Who Loved Castro
Few can say they’ve seen some of the most significant moments of the twentieth century unravel before their eyes. Marita Lorenz is one of them. Born in Germany at the outbreak of WWII, Marita was incarcerated in a Nazi concentration camp as a child. In 1959, she travelled to Cuba where she met and fell in love with Fidel Castro. Yet upon fleeing to America, she was recruited by the CIA to assassinate the Fidel. Torn by love and loyalty, she failed to slip him the lethal pills. Her life would take many more twists and turns — including having a child with ex-dictator of Venezuela, Marcos Pérez Jiménez; testifying about the John G Kennedy assassination; and becoming a party girl for the New York Mafia, as well as a police informant. Caught up in Cold War intrigue, espionage and conspiracy — this is Marita’s incredible true story of a young girl, turned spy.
Diplomatic List
Directory of foreign diplomatic officers in Washington.
Neurotropic Viral Infections
This second edition is a comprehensive study of the viruses that affect the brain and the central nervous system. Along with a focus on the viruses themselves, it addresses the diseases they cause, current treatments and preventive measures. Also discussed are the unique aspects of how viruses cause disease and why certain hosts are more susceptible (e.g., polymorphisms, age, co-morbidities). Because there are 29 cutting edge chapters, written by experts in the fields, Neurotropic Viral Infections has been divided into two separate volumes. Volume 1, Neurotropic RNA Viruses, includes 14 chapters on RNA viruses that cause human disease of the central nervous system ranging from Bornavirus to ...
The Construction of Muslim Identities in Contemporary Brazil
This book represents a contribution to the studies of Muslim minorities, and can be compared and contrasted to the analysis of Islam in Europe and in the USA. Besides presenting data about the largest Muslim community in Latin America, an area of the globe that is still ignored by those who study the “Muslim diaspora”, this book contributes to the understanding of religious dynamics in minority contexts, as well as issues involving integration of immigrants.
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease
Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric diseases. More than 120 leading experts provide a fresh, new assessment of recent molecular, genetic, and genomic advances, offer new insights into disease pathogenesis, describe the newest available therapies, and explore promising areas of therapeutic development. This edition features an updated section on psychiatric disease and expanded, updated chapters on human genomics, gene therapy, and ethical issues. Six new chapters cover congenital myasthenic syndromes, hereditary spastic paraplegia, ion channel disorders, the phakomatoses, beta-galactosidase deficiency, and prion diseases. A Neurologic Gene Map describes the chromosome locus of all the genetic diseases and their gene product where known. The fully searchable online text will be available on a companion Website. (www.rosenbergneuroandpsychdisease.com)
Viral Vectors for Gene Therapy
Viral Vectors for Gene Therapy: Methods and Protocols consists of 30 ch- ters detailing the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Chapter cont- butions provide perspective in the use of viral vectors for applications in the brain and in the central nervous system. Viral Vectors for Gene Therapy: Methods and Protocols contains step-by-step methods for successful rep- cation of experimental procedures, and should prove useful for both experienced investigators and newcomers in the field, including those beginning graduate study or undergoing postdo...
