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Molecular Mechanisms of Bacterial Virulence
The growing body of information on bacteria pathogenic for humans, mammals and plants generated within the past ten years has shown the interesting conservation of newly identified genes that playa direct role in the pathogenic mechanism. In addition to these genes, there are also genes that confer host specificities and other traits important in pathogenesis on these pathogens. In this volume, we have organized the subject areas to best fit the concept on the way bacterial pathogens recognize, interact and invade the host, on the regulation of genes involved in virulence, on the genes involved in the elaboration of toxins and other pathogenic components such as iron sequestering proteins, and on the mechanisms of circumventing the host defense systems. These areas are divided into Sections. Section I covers the first step when the pathogen seeks its host, and Sections II through VI cover subsequent steps leading to pathogenesis while avoiding host defenses. We conclude this work with a chapter summarizing information on examples of virulence mechanisms that are highly conserved.
The pathogenic Yersiniae – advances in the understanding of physiology and virulence
From early studies of the plague causing agent through to comparatively more recent research defining aspects of the type III secretion mechanism, pathogenic Yersinia have served as an inventive model organism for researchers seeking to understand the complexities of bacteria-host cell interactions. In fact, seminal studies on Yersinia virulence mechanisms contributed to the emergence and recognition of the research field – cellular microbiology. Researching Yersinia infection biology continues to bring to light novel discoveries. Assortments of Yersinia whole genome sequencing projects are providing unparalleled insight into bacterial pathogen evolution and environmental adaptation. This ...
The Comprehensive Sourcebook of Bacterial Protein Toxins
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage...
Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions
The opportunistic pathogen Pseudomonas aeruginosa offers a rich variety of biologically relevant topics to explore and serves as a model system to understand the interactions of Gram-negative bacteria with human hosts. The organism adapts readily to most environments. It has a large and variable genome with a great deal of metabolic potential. P. aeruginosa encodes a variety of regulatory systems to fine tune gene expression and integrate environmental signals. This organism can infect both plants and animals and produces a plethora of enzymes and factors that can overcome host defenses. Moreover, it has the ability to change between the states of a sedentary colonizer to an invasive and hig...
Advances and Applications in Microbial Physiology
This book provides a comprehensive and critical review of the work and advancements made so far in the field of microbial physiology. It is divided into five chapters and contains comprehensive information on topics such as bacterial virulence, mechanisms and regulation, bioluminescence, and heat shock proteins, among others. This book shall be of great use to students, research scholars, and teachers pursuing their career in the fields of microbiology, medical sciences and life sciences.
APS Science
None
Protein Secretion in Bacteria
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope pr...
