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Many things have been said and written on the skeletal and non-skeletal effects of vitamin D, but the largest recent interventional studies are generally negative. How should we thus position ourselves in 2020? Should we say “stop” or “not yet”? Indeed, the aging of the population, as well as new challenges and discoveries, is still triggering interest in this old molecule. In this Special Edition of Nutrients, we invited top experts to give their opinion on this important debate. We also encouraged scientists to submit their latest research on nutritional requirements in the general population and in high-risk groups, as well as treatment strategies, epidemiology, analytical updates and new devices for vitamin D measurement and the effect of vitamin D on bone and extra-skeletal health. As readers will see, this Special Issue reinforces the high prevalence of vitamin deficiency and insufficiency in the general population and supports the safety of this low-cost molecule, revealing new perspectives regarding the extra-skeletal effects of vitamin D.
Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.
Research and clinical application of vitamin D has increased dramatically over the past decade stimulated by novel health promotion discoveries and documentation. This book brings together key researchers with their views focusing on the health promotion role of vitamin D. Such information is vital to clinicians, users of vitamin D supplements of all ages and those interested in public policy. The authors document and define many of the key health related roles of vitamin D. Its traditional application in bone and muscle health as well as therapy of arthritis is expanded and clarified with new research. A better understanding of the effects of vitamin D inadequacy is modelled using problems ...
Written in conjunction with the British Dietetic Association, Advanced Nutrition and Dietetics in Nutrition Support provides a thorough and critical review of the fundamental and applied literature in nutrition support. Extensively evidence-based and internationally relevant, it discusses undernutrition, nutritional screening, assessment and interventions, as well as key clinical conditions likely to require nutrition support, and the approaches to managing this in each of these conditions. Clinically oriented, Advanced Nutrition and Dietetics in Nutrition Support is the ideal reference for all those managing undernutrition in a range of clinical areas.
Courageous Surrealist artist Claude Cahun championed freedom at every turn, from rejecting gender norms and finding queer love to risking death to sabotage the Nazis. At the turn of the twentieth century in Nantes, France, Lucy Schwob met Suzanne Malherbe, and lightning struck. The two became partners both artistically and romantically and transformed themselves into the creative personas Claude Cahun and Marcel Moore. Together, the couple embarked on a radical journey of Surrealist collaboration that would take them from conservative provincial France to the vibrancy of 1920s Paris to the oppression of Nazi-occupied Jersey during World War II, where they used art to undermine the Nazi regime. Cahun and Moore challenged gender roles and championed freedom at a time when strict societal norms meant that the truth of their relationship had to remain secret. Featuring ten photographs by Cahun and Moore, this graphic biography by cartoonist Kaz Rowe brings Cahun’s inspiring story to life. Ages twelve and up
Published to accompany an exhibition held at the National Portrait Gallery, London, 9 March-29 May 2017
“This outstanding book will be essential for future studies of naval policy in the period between la Gloire and the Great War.” —The Naval Review This book is the first comprehensive listing in English of more than 1400 warships that were added to the official French navy fleet list between 1 January 1859 and World War I. It includes everything from the largest battleships to a small armoured gunboat that looked like a floating egg. Reflecting the main phases of naval policy, the ships are listed in three separate parts to keep contemporary designs together and then by ship type and class. For each class the book provides a design history explaining why the ships were built, substantia...
In 1786 the French Navy had just emerged from its most successful war of the eighteenth century, having frequently outfought or outmanoeuvred the Royal Navy in battle, and made a major contribution to American independence. The reputation of its ship design and fighting skills never stood higher, yet within a few years the effects of the French Revolution had devastated its efficiency, leading to defeat after defeat. Fine ships continued to be built, but even under Napoleon's dynamic influence the navy never recovered sufficiently to alter the balance of sea power. It was only after 1815 that the navy revived, espousing technical innovation and invention, to produce some of the most advanced...