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RE-MIND2: Comparative Effectiveness of Tafasitamab Plus Lenalidomide Versus Polatuzumab Vedotin/bendamustine/rituximab (pola-BR), CAR-T Therapies, and Lenalidomide/rituximab (R2) Based on Real-world Data in Patients with Relapsed/refractory Diffuse Large B-cell Lymphoma
Abstract: RE-MIND2 (NCT04697160) compared patient outcomes from the L-MIND (NCT02399085) trial of tafasitamab+lenalidomide with those of patients treated with other therapies for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who are autologous stem cell transplant ineligible. We present outcomes data for three pre-specified treatments not assessed in the primary analysis. Data were retrospectively collected from sites in North America, Europe, and the Asia Pacific region. Patients were aged ≥18 years with histologically confirmed DLBCL and received ≥2 systemic therapies for DLBCL (including ≥1 anti-CD20 therapy). Patients enrolled in the observational and L-MIND cohor...
Methods in Endothelial Cell Biology
Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the complex questions. Methods in Endothelial Cell Biology is a comprehensive practical "how-to"-guide summarizing the most relevant established techniques as well as a number of new emerging techniques. Easy-to-follow reliable protocols provide a useful lab bench resource for the experienced researcher and newcomer to the field.
The Art of Iran
Emphasis on architecture, though other forms are discussed - notably sculpture, painting, carpets, and the decorative arts.
Medicine and Technology in Canada, 1900-1950
"Over the past two centuries, technology has played a significant role in the understanding, diagnosis, and treatment of disease in Canada. Technology -- in the form of instruments, devices, machines, drugs, and systems -- has aided medical science, altered medical practice, and changed the illness experience of patients. Nineteenth-century medical technology consisted of predominantly surgical and diagnostic instruments used by individual practitioners. By the twentieth century, large, hospital–based technologies operated by teams emerged as powerful tools in the identification and management of disease [...] Our selection of diseases, research initiatives, and medical treatments highligh...
Victoria and Its Metropolis, Past and Present ...
Contains brief references to Aborigines derived from secondary sources.
Analytical Techniques for Atmospheric Measurement
Almost all of the breakthroughs in understanding the atmospherehave been initiated by field observations, using a range ofinstrumental techniques. Developing or deploying instruments tomake further observations demands a thorough understanding of thechemical and spectroscopic principles on which such measurementsdepend. Written as an authoritative guide to the techniques of instrumentalmeasurement for the atmospheric scientist, research student orundergraduate, Analytical Techniques for Atmospheric Measurementfocuses on the instruments used to make real time measurements ofatmospheric gas and aerosol composition. Topics covered include howthey work, their strengths and weaknesses for a particular task,the platforms on which they have been deployed and how they arecalibrated. It explains the fundamental principles upon which theinstrumental techniques are based (ie what property of a moleculecan be exploited to enable its detection), what limits instrumentalsensitivity and accuracy, and the information that can be gainedfrom their use.
