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Cyteine Protease Trafficking and Function in Giardia Lamblia
In addition, I showed a putative role for the Gl CPs during encystation. Previous work demonstrated that cysteine proteases are involved in encystation-specific vesicle (ESV) biogenesis, specifically cyst wall protein (CWP) processing. I co-localized Gl CP2 and CWPs to ESVs by transfection of Gl CP2-GFP fusion constructs, confocal microscopy and immuno-electron microscopy. Using affinity chromatography and mass spectrophotometry, I also investigated whether Gl CP2 interacts with other proteins during encystation. This work provides insight into the early evolution of a protease trafficking pathway that continues to function in higher eukaryotes and contribute to the goal of validating cysteine proteases as a drug target for Giardiasis .
Gene-Environment Interplay
This volume includes articles on: 1. Social influences on circadian rhythms and sleep in insects. 2. Interplay between social experiences and the genome: epigenetic consequences for behavior. 3. One, two, and many - A perspective on what groups of Drosophila melanogaster can tell us about social dynamics. 4. The circadian clock on the fly: a neurogenetics journey through time.
Handbook of Therapeutic Antibodies
Dieses Nachschlagewerk zu therapeutischen Antikörpern sucht auch in der komplett überarbeiteten 2. Auflage seinesgleichen und bietet 30 % neue Inhalte zu Entwicklung, Herstellung und therapeutischen Anwendungen dieser Biomoleküle.
Supernetworks
Super networks, say Nagurney (management, U. of Massachusetts- Amherst) and Dong (business, State U. of New York-Oswego), are above and beyond existing networks; rather than being made of nodes, links, and flow, are conceptual in scope, graphical in perspective, and predictive when accompanied by a suitable theory. They set out a unifying framework for using such supernetworks by which consumers, producers, intermediaries, and other economic agents can make decisions in the context of a networked economy. In order to identify equilibrium flows and prices, they model the behavior of individual agents and their interactions with the complex network systems. Annotation copyrighted by Book News, Inc., Portland, OR
College
The strengths and failures of the American college, and why liberal education still matters As the commercialization of American higher education accelerates, more and more students are coming to college with the narrow aim of obtaining a preprofessional credential. The traditional four-year college experience—an exploratory time for students to discover their passions and test ideas and values with the help of teachers and peers—is in danger of becoming a thing of the past. In College, prominent cultural critic Andrew Delbanco offers a trenchant defense of such an education, and warns that it is becoming a privilege reserved for the relatively rich. In describing what a true college edu...
Cell Biology
This Second Edition of the highly praised Cell Biology: A Laboratory Handbook brings together 260 new and revised chapters. Each chapter is concisely written and beautifully illustrated, making this attractive four-volume set a worthwhile addition to any desktop, and the up-to-date instructions for biological techniques make this reference the next best thing to having the expert at your side. Dr. Julio Celis and the Associate Editors have drawn on peer review from the scientific community to include 40 percent new material in this much-needed and updated laboratory manual. In one easy to use reference, current and classic protocols are presented in a clear and reader-friendly format that makes this manual a necessity to undergraduate and graduate students as well as technicians and instructors. Features: * Contains more than 40% new material * Provides cell biologists and other life scientists with the most up-to-date instructions for basic and advanced cell biological techniques, including those at the interface between cell and molecular biology * Features uniform style and editing and includes contributions from world-renowned authorities in their respective fields * Contains i
American Elegy
This work is a portrait of America, a way of life, and a familiy that are vanishing even while coming to life on the pages. The author is the final descendent of pioneers who braved death to settle a dangerous frontier to found the Western Pennsylvania town of Parnassus.
Antibody Drug Discovery
Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
