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Advanced Materials for the Conservation of Stone
This book identifies novel advanced materials that can be utilized as protective agents for the preservation of stone. The innovative solutions to stone conservation presented here result in increased sustainability, reduced environmental impact, and increased social and economic benefits. It provides an overview of recent trends and progress in advanced materials applied to stone protection. It also explores the scientific principles behind these advanced materials and discusses their applications to diff erent types of stone preservation efforts. Essential information as well as knowledge on the availability and applicability of advanced nanostructured materials is also provided, with focu...
Inhibitors of Protein–Protein Interactions
Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
Conserving Stone Heritage
The design of treatments for the conservation of stone in historical buildings and works of art is a challenging task, as a deep understanding of the working properties and performance of the available products and methods is required to tackle complex decay patterns. The chapters in this book illustrate the state of the art on traditional and innovative materials and methods for stone conservation, examining current trends and future perspectives. Each of them is focused on describing the consequent phases that complement the spectrum of the conservation intervention: preliminary investigations, condition assessment, and mapping of the deterioration patterns; surface cleaning, with a specif...
Analysis of the MPEG-1 Layer III (MP3) Algorithm using MATLAB
The MPEG-1 Layer III (MP3) algorithm is one of the most successful audio formats for consumer audio storage and for transfer and playback of music on digital audio players. The MP3 compression standard along with the AAC (Advanced Audio Coding) algorithm are associated with the most successful music players of the last decade. This book describes the fundamentals and the MATLAB implementation details of the MP3 algorithm. Several of the tedious processes in MP3 are supported by demonstrations using MATLAB software. The book presents the theoretical concepts and algorithms used in the MP3 standard. The implementation details and simulations with MATLAB complement the theoretical principles. The extensive list of references enables the reader to perform a more detailed study on specific aspects of the algorithm and gain exposure to advancements in perceptual coding. Table of Contents: Introduction / Analysis Subband Filter Bank / Psychoacoustic Model II / MDCT / Bit Allocation, Quantization and Coding / Decoder
Biological Inorganic Chemistry
Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II.
Comprehensive Biochemistry; 12
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Acute Surgical Management
Acute surgical emergencies constitute one of the main clinical aspects that a doctor in hospital practice is expected to handle and manage. This book addresses some of the important and common acute surgical conditions, and has been written from an Asian perspective.
Coloproctology
Coloproctology is a surgical specialty which dynamically changes every few years. There is a profusion of colorectal textbooks but specialty series on particularly complex topics as well as on the specialized management approach for trainees and training colorectal surgeons are actually few. The aim of this text is a superior quality colorectal book written by world experts targeted at senior surgical and colorectal trainees and young consultant coloproctologists in current areas of subspecialty expertise. The structure of the chapters is current and is based on what does not appear and is not addressed in current colorectal textbooks. This series has proven useful in areas already represent...
Building Dynamics
Buildings are increasingly ‘dynamic’: equipped with sensors, actuators and controllers, they ‘self-adjust’ in response to changes in the external and internal environments and patterns of use. Building Dynamics asks how this change manifests itself and what it means for architecture as buildings weather, programs change, envelopes adapt, interiors are reconfigured, systems replaced. Contributors including Chuck Hoberman, Robert Kronenburg, David Leatherbarrow, Kas Oosterhuis, Enric Ruiz-Geli, and many others explore the changes buildings undergo – and the scale and speed at which these occur – examining which changes are necessary, useful, desirable, and possible. The first book ...
Peptide-Based Drug Design
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
