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Stem Cell Technologies meet Stem Cell Biology to Shine New Light into Tropical Infectious Diseases
The aim of this collection of articles is to assemble advances in stem cell-based approaches and their application to the study of parasitic diseases. Tropical parasites, including unicellular protozoan organisms and helminths, represent a major public health burden, particularly in tropical regions of the world. The study of these organisms is significantly hampered by the lack of effective in vitro/ ex vivo culture systems that mimic natural conditions and facilitate a thorough understanding of parasite development and host-parasite interactions. The advent of stem cell technology offers the opportunity to derive the right cell types to culture these parasites. Moreover, stem cell-derived organoids accurately reproduce the particular niche in which the parasites grow, develop, interact with host tissues and reproduce. In addition, particularly for helminths (i.e., multicellular parasites), the identification and characterisation of the parasite’s stem cell system, will be critical to complement our current and future understanding of fundamental biological processes, such as worm maturation, and interaction with the host immune system and microbiota.
Toxoplasmosis of Animals and Humans
Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publi
The Choanoflagellates
A unique account of the biology, ecology and evolution of choanoflagellates - the closest, known, living, unicellular relatives of animals.
Mother Nature Is Trying to Kill You
A fun exploration of the darker side of the natural world reveals the fascinating, weird, often perverted ways that Mother Nature fends only for herself. It may be a wonderful world, but as Dan Riskin (cohost of Discovery Canada’s Daily Planet) explains, it’s also a dangerous, disturbing, and disgusting one. At every turn, it seems, living things are trying to eat us, poison us, use our bodies as their homes, or have us spread their eggs. In Mother Nature Is Trying to Kill You, Riskin is our guide through the natural world at its most gloriously ruthless. Using the seven deadly sins as a road map, Riskin offers dozens of jaw-dropping examples that illuminate how brutal nature can truly b...
The Biology of Parasitism
From the Woods Hole Marine Biological Laboratory--an up-to-date survey of molecular and immunological approaches to the study of parasites responsible for human disease. These concise, provocative essays present empirical findings and personal accounts and critically review current models and theories. Chapters are divided into three sections: the biology of parasites and parasitic disease; parasite immunology; and parasite molecular biology, biochemistry, and genetics. The contributors do not always present the same viewpoint, which makes for lively reading.
Neglected Tropical Diseases - Sub-Saharan Africa
This book provides an overview on the major neglected tropical diseases (NTDs) occurring in Sub-Saharan Africa, such as Leishmaniasis, Buruli Ulcer and Schistosomiasis. In well-structured chapters epidemiology and biology of these parasitic diseases will be discussed in detail. Further, diagnostics and therapeutic approaches as well as prevention strategies will be reviewed. The book will be of interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of the Sub-Saharan region.
Animals
Philosophical controversy over non-human animals extends further back than many realize -- before Utilitarianism and Darwinism to the very genesis of philosophy. This volume examines the richness and complexity of that long history. Twelve essays trace the significance of animals from Greek and Indian antiquity through the Islamic and Latin medieval traditions, to Renaissance and early modern thought, ending with contemporary notions about animals. Two main questions emerge throughout the volume: what capacities can be ascribed to animals, and how should we treat them? Notoriously ungenerous attitudes towards animals' mental lives and ethics status, found for instance in Aristotle and Descar...
Poor Innocent Lad
The Honolulu Star-Bulletin, on the morning of September 20, 1928, told the city that 10-year-old Gill Jamieson, the only son of Hawaiian Trust Company vice president Frederick Jamieson, was dead. What had begun as the search for a kidnap victim quickly turned into a search for Gill's body and for his killer-19-year-old Myles Fukunaga.
