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Drugs for Preventing Postoperative Nausea and Vomiting in Adults After General Anaesthesia: an Abridged Cochrane Network Meta-analysis
Abstract: Postoperative nausea and vomiting is a common adverse effect of anaesthesia. Although dozens of different anti-emetics are available for clinical practice, there is currently no comparative ranking of efficacy and safety of these drugs to inform clinical practice. We performed a systematic review with network meta-analyses to compare, and rank in terms of efficacy and safety, single anti-emetic drugs and their combinations, including 5-hydroxytryptamine3, dopamine-2 and neurokinin-1 receptor antagonists; corticosteroids; antihistamines; and anticholinergics used to prevent postoperative nausea and vomiting in adults after general anaesthesia. We systematically searched for placebo-...
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VEGF Dose Controls the Coupling of Angiogenesis and Osteogenesis in Engineered Bone
Abstract: Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes. A poorly understood aspect is how VEGF dose impacts the coordination between these two processes. Taking advantage of a unique and highly tunable platform, here we dissected the effects of VEGF dose over a 1,000-fold range in the context of tissue-engineered osteogenic grafts. We found that osteo-angiogenic coupling is exquisitely dependent on VEGF dose and that only a tightly defined dose range could stimulate both vascular invasion and osteogenic commitment of progenitors, with significant improvement in bone formation. Further, VEGF dose regulated Notch1 activation and the induction of a specific pro-osteogenic endothelial phenotype, independently of the promotion of vascular invasion. Therefore, in a therapeutic perspective, fine-tuning of VEGF dose in the signaling microenvironment is key to ensure physiological coupling of accelerated vascular invasion and improved bone formation
Who's who in New York (city and State).
Containing authentic biographies of New Yorkers who are leaders and representatives in various departments of worthy human achievement including sketches of every army and navy officer born in or appointed from New York and now serving, of all the congressmen from the state, all state senators and judges, and all ambassadors, ministers and consuls appointed from New York.
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Who's who in New York (city and State)
Containing authentic biographies of New Yorkers who are leaders and representatives in various departments of worthy human achievement including sketches of every army and navy officer born in or appointed from New York and now serving, of all the congressmen from the state, all state senators and judges, and all ambassadors, ministers and consuls appointed from New York.
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