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Drugs for Preventing Postoperative Nausea and Vomiting in Adults After General Anaesthesia: an Abridged Cochrane Network Meta-analysis
Abstract: Postoperative nausea and vomiting is a common adverse effect of anaesthesia. Although dozens of different anti-emetics are available for clinical practice, there is currently no comparative ranking of efficacy and safety of these drugs to inform clinical practice. We performed a systematic review with network meta-analyses to compare, and rank in terms of efficacy and safety, single anti-emetic drugs and their combinations, including 5-hydroxytryptamine3, dopamine-2 and neurokinin-1 receptor antagonists; corticosteroids; antihistamines; and anticholinergics used to prevent postoperative nausea and vomiting in adults after general anaesthesia. We systematically searched for placebo-...
Model Selection for Component Network Meta-analysis in Connected and Disconnected Networks: a Simulation Study
Abstract: Background Network meta-analysis (NMA) allows estimating and ranking the effects of several interventions for a clinical condition. Component network meta-analysis (CNMA) is an extension of NMA which considers the individual components of multicomponent interventions. CNMA allows to "reconnect" a disconnected network with common components in subnetworks. An additive CNMA assumes that component effects are additive. This assumption can be relaxed by including interaction terms in the CNMA. Methods We evaluate a forward model selection strategy for component network meta-analysis to relax the additivity assumption that can be used in connected or disconnected networks. In addition, ...
Die geburtshilfliche Anästhesie
Das vorliegende Buch bietet umfassendes Praxiswissen rund um die Analgesie und Anästhesie bei Schwangeren und wendet sich an alle Anästhesisten in Aus- und Weiterbildung, die sich für diese verantwortungsvolle Aufgabe wappnen möchten. Dargestellt werden alle relevanten Allgemeinanästhesie- und Regionalanästhesieverfahren, sowohl für geburtshilfliche, als auch für nicht-geburtshilfliche Eingriffe. Das hochkarätige, interdisziplinäre Autorenteam, bestehend aus Anästhesisten, Geburtshelfern, Pädiatern und Neonatologen vermittelt praxisnah und verständlich die Grundlagen und Besonderheiten aus dem jeweiligen Blickwinkel. Dies garantiert ein grundlegendes Verständnis der komplexen Z...
Error and Fraud
This fascinating book gives readers an appreciation of how biomedical research should work and how the reality is all too often seriously flawed. Explaining the logical basis of the different research approaches used by biomedical research scientists and their relative merits, it will help readers to make more realistic appraisal of media reports linking aspects of lifestyle, environment or diet to health outcomes and thus judge whether such claims are a real effect worthy of consideration for behavior change or deserving of further research resources. Key features: increases awareness of research fraud and some of the characteristics of fraudulent science and scientific fraudsters shows tha...
