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The Megaloblastic Anaemias
Vitamin B12.
Megaloblastic anaemia
Suspect megaloblastic anaemia if the patient presents with macrocytic anaemia, i.e. increased erythrocyte mean cell volume (MCV). Establish the aetiology of the anaemia (usually deficiency of vitamin B12 or folates). Establish the reason for vitamin deficiency. Start specific treatment and monitor treatment response.
The Megaloblastic Anaemias
Megaloblastic anaemia is a common disorder encountered in daily haematological practice. The possibility of such diagnosis needs to be considered with every blood count showing an increase in red cell size. The clinical importance of megaloblastic anaemia is that it is commonly due to a deficiency of either folate or cobalamin (vitamin B12). Therapy with the appropriate vitamin produces very gratifying clinical benefits. Although a clinical suspicion of megaloblastic anaemia may initiate appropriate investigations, diagnosis must be made in the laboratory from examination of the blood and marrow. The book has been considerably shortened for the new edition, nevertheless is a full account of the field for the practising haematologist and for the student specialising in haematology
Folates and Cobalamins
The folate and cobalamin vitamins are extensively analyzed in this volume multi-authored by international experts. A variety of perspectives covers biochemical, metabolic, nutritional, and other medical aspects. The clinical aspects deal with the various consequences of a deficiency in both infants and adults; the therapeutic aspects include studies on methotrexate pharmacokinetics. The relationship between these vitamins and some pediatric, gastroenterologic, neurologic, and geriatric diseases is successively presented in this book; it serves as a complete overview to the numerous fields in which folate and cobalamin are involved.
Pernicious Anaemia
This book could save you years of ill health! Vitamin B12 definicency, often caused by pernicious anaemia, can be a devastating condition if left untreated, leaing to irreversible nerve damage and disability after years of exhaustion and mental 'fog'. Its symptoms creep up on sufferers and are under-recognised by doctors; tests to confirm it and underlying pernicious anaemia, are problematic. Martyn Hooper, the founder of the Pernicious Anaemia Society, now brings together vital information about the condition and real-life stories - including his own and those of many members of the society - that will help sufferers and their friends and fmailies recognise the condition and understand how best to tackle it. In particular, the book draws on the findings of a survey of society members that give new clarity to the complex issues involved.
