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Vitamin B12.
Megaloblastic anaemia is a common disorder encountered in daily haematological practice. The possibility of such diagnosis needs to be considered with every blood count showing an increase in red cell size. The clinical importance of megaloblastic anaemia is that it is commonly due to a deficiency of either folate or cobalamin (vitamin B12). Therapy with the appropriate vitamin produces very gratifying clinical benefits. Although a clinical suspicion of megaloblastic anaemia may initiate appropriate investigations, diagnosis must be made in the laboratory from examination of the blood and marrow. The book has been considerably shortened for the new edition, nevertheless is a full account of the field for the practising haematologist and for the student specialising in haematology
The folate and cobalamin vitamins are extensively analyzed in this volume multi-authored by international experts. A variety of perspectives covers biochemical, metabolic, nutritional, and other medical aspects. The clinical aspects deal with the various consequences of a deficiency in both infants and adults; the therapeutic aspects include studies on methotrexate pharmacokinetics. The relationship between these vitamins and some pediatric, gastroenterologic, neurologic, and geriatric diseases is successively presented in this book; it serves as a complete overview to the numerous fields in which folate and cobalamin are involved.
This book deals with a very common condition, anemia, which might interest not only the physicians but also other healthcare professionals and researchers dealing with anemic patients. The objective of this book was to collect and compile up-to-date information from reputable researchers of different countries of the world to disseminate the latest information about the common types of anemia in some specific physiological and pathological conditions including pathophysiology and the use of algorithms as a tool to minimize the laboratory tests and accurate diagnosis of the underlying cause. In total, there are 13 chapters in this book where the authors shared their research findings and real-life experiences in managing their patients with anemia.