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Genome-wide Association Study Identifies Genetic Loci for Self-reported Habitual Sleep Duration Supported by Accelerometer-derived Estimates
Abstract: Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p
The Metabolic Syndrome
The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions an...
Associations Between Sleep Health and Grey Matter Volume in the UK Biobank Cohort (n
Abstract: As suggested by previous research, sleep health is assumed to be a key determinant of future morbidity and mortality. In line with this, recent studies have found that poor sleep is associated with impaired cognitive function. However, to date, little is known about brain structural abnormalities underlying this association. Although recent findings link sleep health deficits to specific alterations in grey matter volume, evidence remains inconsistent and reliant on small sample sizes. Addressing this problem, the current preregistered study investigated associations between sleep health and grey matter volume (139 imaging-derived phenotypes) in the UK Biobank cohort (33 356 partic...
New Transcription Factors and Their Role in Diabetes and Therapy
This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease.*Applies molecular biology to transcriptional regulation of metabolism and obesity*Underscores the clinical relevance of transcription factors*Provides a valuable overview of the current status of the field
The Genetics of Obesity
Obesity has taken an epidemic turn in the United States. This books helps teens understand the physical underpinnings of obesity, as well as the behavior patterns that allow the epidemic to continue spreading. The book examines the genetic connections, inheritance, gene mutations, and how genes influence obesity. Readers will learn ways to overcome genetic links to obesity, including nutrition, healthy eating habits, and exercise tips.
Big Data Analytics in Genomics
This contributed volume explores the emerging intersection between big data analytics and genomics. Recent sequencing technologies have enabled high-throughput sequencing data generation for genomics resulting in several international projects which have led to massive genomic data accumulation at an unprecedented pace. To reveal novel genomic insights from this data within a reasonable time frame, traditional data analysis methods may not be sufficient or scalable, forcing the need for big data analytics to be developed for genomics. The computational methods addressed in the book are intended to tackle crucial biological questions using big data, and are appropriate for either newcomers or...
Anthropological Perspectives on Aging
An in-depth and wide-ranging approach to the study of older adults in society Taking a holistic approach to the study of aging, this volume uses biological, archaeological, medical, and cultural perspectives to explore how older adults have functioned in societies around the globe and throughout human history. As the world’s population over 65 years of age continues to increase, this wide-ranging approach fills a growing need for both academics and service professionals in gerontology, geriatrics, and related fields. Case studies from the United States, Tibet, Turkey, China, Nigeria, and Mexico provide examples of the ways age-related changes are influenced by environmental, genetic, socio...
Public Health Nutrition
Mbuya, Kimberly Morland, Lynnette M. Neufeld, Vanessa Oddo, Cynthia Ogden, Colin Rehm, Scott Richardson, Sarah Ross-Viles, Marie Ruel, Julie Ruel-Bergeron, Garrison Spencer, Marie Spiker, Andrew Thorne-Lyman, Alison Tumilowicz, Kelsey Vercammen, Marissa Zwald
The Genetics of Type 2 Diabetes and Related Traits
This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.
Recent Advances in Growth Research
Growth in mammals encompasses several stages, from intrauterine growth through infancy and childhood to adolescence. Each of these phases is characterized by very specific nutritional, molecular and endocrine perspectives which, under ideal conditions, allow the organism to achieve its genetically programmed growth patterns. In this book, an international panel of experts addresses these topics in a historical, physiological and social perspective. The first part investigates the genetic, epigenetic, molecular and nutritional determinants of intrauterine and postnatal growth. Part two deals with non-evolutionary changes which occurred in the recent past, such as changes in body size in utero...
