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Statistical and Evolutionary Analysis of Biological Networks
Networks provide a very useful way to describe a wide range of different data types in biology, physics and elsewhere. Apart from providing a convenient tool to visualize highly dependent data, networks allow stringent mathematical and statistical analysis. In recent years, much progress has been achieved to interpret various types of biological network data such as transcriptomic, metabolomic and protein interaction data as well as epidemiological data. Of particular interest is to understand the organization, complexity and dynamics of biological networks and how these are influenced by network evolution and functionality. This book reviews and explores statistical, mathematical and evolut...
Transactions on Computational Systems Biology III
The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems-oriented point of view of biological phenomena. This, the third Transactions on Computational Systems Biology volume, edited by Emanuela Merelli, Pedro Pablo Gonzalez and Andrea Omicini, is devoted to considerably extended versions of selected papers presented at the International Workshop on Network Tools and Applications in Biology (NETTAB 2004), held at the University of Camerino, in Camerino, Italy, in September 2004. Dedicated especially to models and metaphors from biology to bioinformatics tools, the 10 papers selected for the special issue cover a wide range of bioinformatics research such as data visualisation, protein/RNA structure prediction, motif finding, modelling and simulation of protein interaction, genetic linkage analysis, and notations and models for systems biology.
Investigations in Sociohistorical Linguistics
In the last five hundred years or so, the English language has undergone remarkable geographical expansion, bringing it into contact with other languages in new locations. It also caused different regional dialects of the language to come into contact with each other in colonial situations. This book is made up of a number of fascinating tales of historical-sociolinguistic detection. These are stories of origins - of a particular variety of English or linguistic feature - which together tell a compelling general story. In each case, Trudgill presents an intriguing puzzle, locates and examines the evidence, detects clues that unravel the mystery, and finally proposes a solution. The solutions are all original, often surprising, sometimes highly controversial. Providing a unique insight into how language contact shapes varieties of English, this entertaining yet rigorous account will be welcomed by students and researchers in linguistics, sociolinguistics and historical linguistics.
Romans, Barbarians, and the Transformation of the Roman World
One of the most significant transformations of the Roman world in Late Antiquity was the integration of barbarian peoples into the social, cultural, religious, and political milieu of the Mediterranean world. The nature of these transformations was considered at the sixth biennial Shifting Frontiers in Late Antiquity Conference, at the University of Illinois at Urbana-Champaign in March of 2005, and this volume presents an updated selection of the papers given on that occasion, complemented with a few others,. These 25 studies do much to break down old stereotypes about the cultural and social segregation of Roman and barbarian populations, and demonstrate that, contrary to the past orthodox...
The Black Box of Biology
In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology w...
Modelling Proteasome Dynamics in a Bayesian Framework
Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
Biological Network Analysis
Biological Network Analysis: Trends, Approaches, Graph Theory, and Algorithms considers three major biological networks, including Gene Regulatory Networks (GRN), Protein-Protein Interaction Networks (PPIN), and Human Brain Connectomes. The book's authors discuss various graph theoretic and data analytics approaches used to analyze these networks with respect to available tools, technologies, standards, algorithms and databases for generating, representing and analyzing graphical data. As a wide variety of algorithms have been developed to analyze and compare networks, this book is a timely resource.
How the West Won
Finally the Truth about the Rise of the West Modernity developed only in the West—in Europe and North America. Nowhere else did science and democracy arise; nowhere else was slavery outlawed. Only Westerners invented chimneys, musical scores, telescopes, eyeglasses, pianos, electric lights, aspirin, and soap. The question is, Why? Unfortunately, that question has become so politically incorrect that most scholars avoid it. But acclaimed author Rodney Stark provides the answers in this sweeping new look at Western civilization. How the West Won demonstrates the primacy of uniquely Western ideas—among them the belief in free will, the commitment to the pursuit of knowledge, the notion that...
The 10,000 Year Explosion
Two leading researchers make the controversial argument that the human species is still measurably evolving in important ways--in fact, faster than ever before.
Massive Graph Analytics
"Graphs. Such a simple idea. Map a problem onto a graph then solve it by searching over the graph or by exploring the structure of the graph. What could be easier? Turns out, however, that working with graphs is a vast and complex field. Keeping up is challenging. To help keep up, you just need an editor who knows most people working with graphs, and have that editor gather nearly 70 researchers to summarize their work with graphs. The result is the book Massive Graph Analytics." — Timothy G. Mattson, Senior Principal Engineer, Intel Corp Expertise in massive-scale graph analytics is key for solving real-world grand challenges from healthcare to sustainability to detecting insider threats, cyber defense, and more. This book provides a comprehensive introduction to massive graph analytics, featuring contributions from thought leaders across academia, industry, and government. Massive Graph Analytics will be beneficial to students, researchers, and practitioners in academia, national laboratories, and industry who wish to learn about the state-of-the-art algorithms, models, frameworks, and software in massive-scale graph analytics.
