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Interferon-driven Immune Dysregulation in Common Variable Immunodeficiency-associated Villous Atrophy and Norovirus Infection
Abstract: Purpose About 15% of patients with common variable immunodeficiency (CVID) develop a small intestinal enteropathy, which resembles celiac disease with regard to histopathology but evolves from a distinct, poorly defined pathogenesis that has been linked in some cases to chronic norovirus (NV) infection. Interferon-driven inflammation is a prominent feature of CVID enteropathy, but it remains unknown how NV infection may contribute. Methods Duodenal biopsies of CVID patients, stratified according to the presence of villous atrophy (VA), IgA plasma cells (PCs), and chronic NV infection, were investigated by flow cytometry, multi-epitope-ligand cartography, bulk RNA-sequencing, and RT...
L'omicidio di Valle Giulia
Un omicidio avvenuto mentre si consumava la battaglia di Valle Giulia porterà, più di mezzo secolo dopo, a scoprire una verità sconcertante e a fare i conti con un lato oscuro dell’umanità. Flavia con il suo inseparabile Golden retriever Nous indagherà senza sosta, affiancata da Gianni e Clara, tra i quartieri romani dei Parioli e San Lorenzo, in un viaggio catartico e di crescita. Michele Proietti, rifugiatosi in un palazzo per sfuggire alla guerriglia del 1° marzo 1968 scoppiata intorno alla Facoltà di Architettura a Roma, incontra Laura Dominici. La donna sarà in seguito trovata morta e il marito Edoardo ferito. Michele verrà accusato e condannato per furto, aggressione ed omic...
Cellular Primary Immunodeficiencies
This volume of the series Rare Diseases of the Immune System presents detailed state of the art knowledge on the cellular primary immunodeficiencies; it includes extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the T cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel cellular PID genes and related clinical applications, mucosal T cells, and the various clinical phenotypes of cellular PIDs. Cellular Primary Immunodeficiencies will be of high value for immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD, Master and PhD students.
