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Circadian Clocks: Role in Health and Disease
This book sheds new light on the molecular mechanisms that generate circadian rhythms. It examines how biological rhythms influence physiological processes such as sleep, hormone synthesis and secretion, immunity, kidney function, the cardiovascular system, blood pressure, and the digestive system. Clinical implications are considered while exploring the impact of rhythms on neuropsychiatric disorders and chronotherapy’s potential for reducing cardiovascular risk. Offering a cross-section of expertise in both basic and translational (bench-to-bedside) research, this book serves as a guide for physicians and scientists who wish to learn more about the impact of circadian rhythms on physiological processes in health and disease.
Epithelial Transport Physiology
Biological cell membranes regulate the transfer of matter and information between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism. This volume contains a series of reviews that are c- cerned with how epithelial plasma membranes regulate the transport of solutes between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of various solutes across an epithelial cell membrane. This volume is devoted to a diversity of epithelial transport mechanisms in rep- sentative cell membranes of a variety of living things. The ?rst section of the book (Chapters 1–6) focuses on mechanisms of solute transport in epithelia of inver- brates. The last section which comprises ten chapters (Chapters 7–16) deals with solute transporters in epithelial cell membranes of vertebrates. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various epithelial solute transporters.
The Inner Clock
How the groundbreaking science of body clocks can help you sleep better, feel happier and improve your overall health 'The Inner Clock explores the strange new science of why your circadian rhythms fall out of sync – and how to get them back on track to live a happier, healthier life' JAMES NESTOR, BESTSELLING AUTHOR OF BREATH Your body contains a symphony of tiny timepieces, synchronised to the sun and subtle signals in your environment and behaviour. But modern insults like artificial light, contrived time zones and late-night meals can wreak havoc on your internal clocks. Armed with advances in biology and technology, a circadian renaissance is reclaiming those lost rhythms. The Inner C...
Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Cardio-Physiology Challenging Empirical Philosophy
With this volume of three essays, the authors want to create an opportunity for dialogue between different disciplines by taking a closer look at three cardio-physiological examples. In the essays presented, we will look at the exploration of different cardiological topics from the 20th century, all of which have contributed to a better understanding of certain aspects of cardiac activity. Not only do these insights provide a more complete picture of these cardiac phenomena, but it is also within this context that we can look for and into the patterns of regularities which govern this living organism. Our goal is to stimulate a dialogue on the philosophy of science in the spirit of Hans Reichenbach.
OUCH! The Pain of Modern Civilization
Isn’t it ironic that information about healthy living is in such abundance yet people are more confused than ever? In excess of 80% of today’s healthcare costs are spent treating chronic diseases like diabetes, hypertension, high cholesterol, heart disease, cancer, and obesity. This is a function of our modern society, characterized by Overnutrition, Under-activity, Circadian rhythm disruption, and a Hectic and stressful lifestyle—or OUCH—unlike any we’ve seen before. In OUCH! The Pain of Modern Civilization, authors Dr. Ajay Issar and Alka Issar offer a four-factor model of chronic disease that not only links these behaviours with their physical consequences, but explains in detai...
Sodium and Water Homeostasis
This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.
