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Targeted Protein Degradation
This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.
The Regulation of Global DeSUMOylation by Human SUMO-specific Proteases
SUMOylation - the covalent tagging of a target protein with a SUMO (small ubiquitin-related modifier) molecule - has recently emerged as an important post-translational modification in regulating a wide array of biological events. SUMOylation is a dynamics process, where SUMO-specific proteases (SENPs) process proSUMO molecules and also deconjugate them from substrates. My dissertation focuses on the deconjugating activity of SENPs and addresses the role they play in regulating the global SUMOylation "status quo" of eukaryotic cells. SENPs are among the most specific proteases and only cleave SUMO molecules, yet they exhibit substantial substrate specificity among SUMO paralogs. To address t...
Still Standing
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Handbook of Proteolytic Enzymes
Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing f...
Hungarian Heritage
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Miklos Pogany
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