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Targeted Protein Degradation
This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.
Climate-Resilient Agriculture
Developing climate-smart crops is vital to securing food security around the world. This new book discusses the state-of-the-art technologies that can help to mitigate plant abiotic stresses in cultivated crops. It covers the current aspects of climate-resilience agriculture, including the crucial physiological, biochemical, and molecular aspects of cultivated crops under stress conditions, which play a pivotal role in developing climate-smart crops. The volume explores breeding, omics, genetic engineering, bioengineering of metabolic pathways, artificial intelligence, and more. Key features: Addresses the current and future challenges of climate changes on food security Details the impact o...
Armor
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Nanotechnology for Sustainable Agriculture
This new volume explores the important and cutting-edge roles that nanotechnology can play in facilitating sustainable agriculture. It provides recent updates on nanobiotechnology in soil science, plant breeding, food science, agricultural tool design and utilization, as well as the impacts of such approaches on properties of soils and plants. The book looks at the use of nanotechnology for crop production and protection, in the creation and application of pesticides, to enhance soil fertility and soil health, as a mitigating factor of plant abiotic stress, and more. The volume explores emerging nanotechnological tools and techniques for crop improvement that include space-inspired speed breeding for crop improvement, nanoparticles as sensing materials, plant nanobionics, nanopore DNA sequencing, and more.
Governance, Identity, and Counterinsurgency: Evidence from Ramadi and Tal Afar (enlarged Edition)
With the last departure of U.S. combat forces from Iraq in 2011 and a drawdown in Afghanistan already underway, the current era of American counterinsurgency may be coming to a close. At the same time, irregular threats to U.S. national interests remain, and the future may hold yet more encounters with insurgents for the U.S. military. Accordingly, the latest Defense strategic guidance has called on the Department of Defense (DoD) to "retain and continue to reine the lessons learned, expertise, and specialized capabilities" from the wars in Iraq and Afghanistan. This monograph is a contribution to this ongoing effort to institutionalize the military's understanding of counterinsurgency, building on its hard-won recent experience. Michael Fitzsimmons examines two case studies drawn from some of the darkest months of conlict in Iraq...
In Contact!
Case studies include lethal and nonlethal missions performed by soldiers in Iraq and Afghanistan. The events chronicled span the spectrum of participants from officers to noncommissioned officers, and from combat units to support personnel, all in contact with a vicious and unforgiving enemy.
