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The Use of Biomarkers to Explore Inflammation and Phenotypes During Exacerbations of Chronic Obstructive Pulmonary Disease
Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous. In particular the association of airway inflammation with pathogens during exacerbations of COPD remains largely unknown. The identification of biomarkers of COPD aims to characterise and phenotype COPD and COPD exacerbations, explore mechanisms of pathogenesis and provide decisions regarding targeted treatment strategies. After validating the Meso scale discovery platform, biomarkers in stable state and during exacerbations COPD were explored. COPD exacerbations were associated with increased systemic and pulmonary inflammation and exacerbations associated with bacteria, virus and sputum eosinophils could be id...
Diagnosis and Treatment in Internal Medicine
Diagnosis and Treatment in Internal Medicine equips trainee doctors with the essential skills and core knowledge to establish a diagnosis reliably and quickly, before outlining the management of the clinical condition diagnosed. Organised into three sections, the first provides a vital overview, whilst the second focuses on common presentations and diagnoses. Uniquely, this new book shows readers how to turn symptoms into a list of diagnoses ordered by probability - a differential diagnosis. Experienced consultants who teach trainees every day demonstrate how to derive an ordered differential diagnosis, how to narrow this down to a single diagnosis and if not, how to live with diagnostic uncertainty. The final section provides a comprehensive account of the management of system-based syndromes and diseases. Highly-structured chapters emphasize how common conditions present, how to approach a diagnosis, and how to estimate prognosis, treatment and its effectiveness. An onus is placed on the development of crucial diagnostic skills and the ability to devise evidence-based management plans quickly and accurately, making this an ideal text for core medical trainees.
Respiratory E-Book
Respiratory Medicine is a new e-book in a collection of subject-themed e-books containing relevant key articles from Medicine. The e-books provide a perfect source of revision for post-graduate exams in clinical medicine and portfolio material for life-long learning. As well as mapping to the UK Core Medical Training curriculum, these e-books also enable anyone with a short-term interest in a specific area to buy individual articles at a price-point that will give affordable access to all readers (from medical students to GPs and practitioners in related areas). The quality of user experience on mobiles, tablets and laptops will be an added bonus for learning on the move. The whole board has...
The Lung Microbiome
Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Chronic Obstructive Pulmonary Disease Exacerbations
Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat
Respiratory Epidemiology
Over the last decade, the volume of research into the pathophysiology and genetics of pulmonary diseases has increased greatly. This has led to the development of new treatments and therapies for many diseases, including lung cancer, asthma and cystic fibrosis. This issue of the ERS Monograph comprehensively demonstrates the developments in respiratory medicine in recent years. It outlines the importance of epidemiology in respiratory medicine, and will prove a methodological tool that will help disease management. It should also be used as an advocacy tool for the sake of public health.
The Medical Register
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Fatal Asthma
Written by an international team of physicians experienced in all aspects of asthma care, this opportune work defines, with exceptional clarity, the atopic and environmental risk factors attributable to fatal asthma-recommending means of lowering the incidence of life-threatening episodes through timely prognosis and the start of treatment with drugs that reduce and prohibit the remodeling process. Establishes the criteria for fatality-prone asthma individuals! Exploring elements that contribute to fatal asthma attacks, such as socioeconomic deprivation inadequate medical care genetic susceptibility to serious asthma delayed recognition and introduction of suitable treatment, and early airwa...
