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The Use of Biomarkers to Explore Inflammation and Phenotypes During Exacerbations of Chronic Obstructive Pulmonary Disease
Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous. In particular the association of airway inflammation with pathogens during exacerbations of COPD remains largely unknown. The identification of biomarkers of COPD aims to characterise and phenotype COPD and COPD exacerbations, explore mechanisms of pathogenesis and provide decisions regarding targeted treatment strategies. After validating the Meso scale discovery platform, biomarkers in stable state and during exacerbations COPD were explored. COPD exacerbations were associated with increased systemic and pulmonary inflammation and exacerbations associated with bacteria, virus and sputum eosinophils could be id...
The Asthmas
The field of asthma has expanded in the last decade with specific drugs targeting the disease mechanisms. This book is an updated treatise covering diagnoses, phenotypes and endotypes of asthma along with its management. It includes diagnostic work-up which is required prior to medical assistance and basic immunology assessment, illustrating the types, severity, number of exacerbations due to disease activity, allergy or infections. As the treatment selection has changed from one size fits all to precision-based medicine, it aims to refine asthma management with right medication usage, neither overuse nor underuse, and initiation of the new hospital administered biologic drugs. Key Features • Covers both respiratory physiology and airway inflammation • Highlights the use of biologic drugs • Discusses precision-based medicine • Explores the comorbidities through clinical cases
Diagnosis in Acute Medicine
Undergraduate and postgraduate teaching increasingly favours a symptom-based approach to diagnosis. Unlike many other textbooks in acute medicine, this book reflects this shift in emphasis, presenting a logical and structured approach to the diagnosis and initial management of acutely unwell adults. It discusses the relevant pathophysiology of each clinical presentation, and provides a comprehensive table of differential diagnoses, highlighting common causes. The book's description of generic emergency management emphasises important diagnoses, and explains relevant history, examination findings and investigations involved in assessment or diagnosis. Senior medical students and junior doctor...
Supportive Care in Respiratory Disease
The second edition of this popular title in the Supportive Care series focuses on the aetiology, diagnosis and management of respiratory diseases, emphasising symptoms, quality of life and psychosocial support. The underlying theme of the book is the application of modern research-based knowledge, in a humane way, for those with advancing disease.
Clinical Respiratory Medicine
This comprehensive clinical textbook examines all aspects of respiratory medicine. The editors take a practical approach to the diagnosis and management of patients with the full range of pulmonary disorders, making this your ideal source for reference in clinical practice. Fully revised, this essential volume includes new chapters on PET imaging, implications of genetic research, oxygen therapy, and rehabilitation. Now an Expert Consult title, it comes with access to the complete contents of the book online, including all of the book's images, downloadable for use in presentations. Provides complete clinical coverage so you can Better manage and treat patients with pulmonary disease. Uses t...
Clinical Respiratory Medicine E-Book
Clinical Respiratory Medicine provides practical guidance to help you more effectively diagnose and manage the full range of pulmonary disorders, including those seen in today’s most challenging patient populations. In print and online, this medical reference book delivers the answers you need to ensure the best outcomes. Better manage and treat patients with pulmonary disease with complete clinical coverage of the critical information relevant to your everyday practice, presented in a templated, user-friendly format. Find critical information quickly with the help of diagnostic algorithms. Thoroughly understand the needs and recognize co-morbidities of particular patient populations through entirely new chapters on lung structure, echocardiography, and obesity and its effects. Access the latest research and advancements in lung cancer, benign tumors, and the importance of pulmonary physiology in understanding lung function and the disease processes that occur. Watch and learn. Over 80 videos of practical procedures and interactive review questions are available online at www.expertconsult.com.
Severe Asthma
Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Allergy and Allergic Diseases
Reserve your copy now This two volume book is an outstanding reference source on allaspects of allergy and allergic diseases. Covering virtually everyallergic condition, from the immunological and molecular basis ofthe allergic response to future trends in allergic diseaseprevention, this new international editorial team (A.B.Kay, JeanBousquet, Pat Holt and Allen Kaplan) have completely revised andupdated the text, from both a scientific and clinical perspective.References will continue to be added to the text until it goes topress making this the most up-to-date book available in thefield. This second edition consists of more than 1,800 pages containedwithin 98 chapters. The price includes a fully searchable companion CD ROM with thecomplete text and over 300 images from the book in full colour.
