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Biology of Fertilization, Volume 1: Model Systems and Oogenesis is the first in a three-volume series that gathers various lines of research about reproduction in general and fertilization in particular. Knowledge about cell biology, immunobiology, biochemistry, biophysics, and molecular genetics has progressed significantly beyond our understanding of some aspects of fertilization. Components of these constitute ""model systems."" The present volume includes reviews of such systems, some relatively simple model systems in lower organisms, sex-determining mechanisms, and oogenesis. The book contains 12 chapters organized into two sections. Section I includes studies on evolution, reproductive success, and immortality of the germ line; the structures and mechanisms involved in fertilization problems; and fertilization in Paramecium. Section II on oogenesis includes studies on gamete differentiation; sex-determining role of the H-Y antigen in mammals and non-mammals; the mechanism of starfish oocyte maturation; meiotic arrest in animal oocytes; and the mitotic and meiotic aspects of the mammalian germ cell life cycle.
During the last decade, research in Uncertainty Quantification (UC) has received a tremendous boost, in fluid engineering and coupled structural-fluids systems. New algorithms and adaptive variants have also emerged.This timely compendium overviews in detail the current state of the art of the field, including advances in structural engineering, along with the recent focus on fluids and coupled systems. Such a strong compilation of these vibrant research areas will certainly be an inspirational reference material for the scientific community.
Ca2+ signaling in neurons is characterized by highly restricted and dynamic gradients called Ca2+ waves, spikes, transients and puffs depending upon their corresponding spatial and temporal features. Based on this strict segmentation the Ca2+ ion provides a versatile basis for complex signaling in neuronal subcompartments with a spatial resolution of micro- and nanodomains. The multitude of Ca2+-regulated processes requires specialized downstream processing machinery, translating the Ca2+ signal into alterations of cellular processes. The broad range of different Ca2+-triggered phenomena in neurons, ranging from neurotransmission to gene expression, is reflected by the existence of a multitu...
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.
Surveys the control of human spinal cord circuits, in normal movement and in disease states.
From the New York Times bestselling author of Mexican Gothic and Velvet Was the Night comes a dreamy reimagining of The Island of Doctor Moreau set against the backdrop of nineteenth-century Mexico. 'The deeply atmospheric novel blends horror, science fiction, and historical events' Time, 100 'Must Read Books of 2022' Carlota Moreau: growing up in a distant and luxuriant estate, safe from the conflict and strife of the Yucatan peninsula, she is the only daughter of an eccentric, and dangerous, genius. His experiments, a motley group of hybrid monstrosities, are blindly loyal to their creator. Into Carlota's strange but perfectly balanced world comes Eduardo Lizalde, the charming, careless so...