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This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.
Advances in Marine Biology was first published in 1963. Now edited by A.J. Southward (Marine Biological Association, UK), P.A. Tyler (Southampton Oceanography Association, UK), C.M. Young (Harbor Branch Oceanographic Institution, USA) and L.A. Fuiman (University of Texas, USA), the serial publishes in-depth and up-to-date reviews on a wide range of topics which will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as The Biology of Calanoid Copepods.* Includes over 55 tables of descriptive data* Covers such topics as coral reefs, southern ocean cephalopods, seagrass and mangrove habitats, and much more* 4 reviews authored by experts in their relevant fields of study
This comprehensive contributed volume presents an account of current research and applications of chemical processes occurring at the interfaces of water with naturally occuring solids. Interactions of solutes with the solid surfaces are looked at from a mechanistic and dynamic point of view rather than a descriptive one. Processes discussed and concepts presented are applicable to all natural waters (oceans and fresh waters as well as soil and sediment water systems) and to the surfaces of natural solids such as minerals, soils, sediments, biota, and humus. Chapters progress from theoretical models and laboratory studies to applications in natural water, soil, and geochemical systems, empha...
Europe is a continent with a high coast-to-surface ratio, and European seas encompass a broad range of settings and regimes. The sustainable development of living and non-living marine resources, the protection of the marine environment and the provision of marine-based services are critical to economic prosperity and to the quality of life of European citizens. Addressing these concerns, marine-science researchers conducted a workshop reviewing major topics of European marine research. This publication contains overview and thematic background papers, as well as reports and recommendations for future research covering topics such as ocean-climate coupling, biogeochemistry, coastal and shelf processes, and ecosystem functioning/biodiversity.
This handbook presents the most recent technological advances and applications in the areas of biomedical photonics. This second edition contains introductory material and covers the state-of-the-art methods and instrumentation for biomedical photonic technologies. It integrates interdisciplinary research and development critically needed for scientists, engineers, manufacturers, teachers, students, and clinical providers to learn about the most recent advances and predicted trends in instrumentation and methods as well as clinical applications in important areas of biomedical photonics. Extensive references are provided to enhance further study.
Electrochemistry plays a key role in a broad range of research and applied areas including the exploration of new inorganic and organic compounds, biochemical and biological systems, corrosion, energy applications involving fuel cells and solar cells, and nanoscale investigations. The Handbook of Electrochemistry serves as a source of electrochemical information, providing details of experimental considerations, representative calculations, and illustrations of the possibilities available in electrochemical experimentation. The book is divided into five parts: Fundamentals, Laboratory Practical, Techniques, Applications, and Data. The first section covers the fundamentals of electrochemistry...
This book highlights Indian scientific endeavours and contributions to answering the vast multitude of questions posed by our changing environment. The International Ocean Discovery Program (IODP) explores Earth’s history and dynamics using deep ocean drilling platforms to recover the data locked inside seafloor sediments and rocks. Since 2009, Indian scientists have been actively engaged in these expeditions. Scientists from various Earth Science disciplines have seized this opportunity to offer their expertise in order to help unravel the mysteries of the past – by delving deep into the valuable sedimentary records of our oceans. This book presents a compilation of some of their most important findings to motivate and encourage young minds for their enhanced role in the cutting edge science of ocean drilling.
Examines the latest innovations and the overall impact of PCR on areas of molecular research.
Hardbound. The first chapter focuses on one aspect of one of the most stimulating topics in the whole of lanthanide science: the dual valence state elements Ce, Pr and Tb (valences of 3 and 4) and Sm, Eu, Tm and Yb (valences of 2 and 3). The authors bring us up to date on the status of our knowledge of valence fluctuation and heavy fermion 4f systems as gleaned from neutron scattering experiments. The major topics include cerium-based valence fluctuation systems, cerium-based heavy fermion materials and ytterbium-based materials. The remaining quarter of the chapter deals with samarium-, europium- and thulium-based systems.The next chapter deals with the thermal conductivity of rare earth containing materials and is the first major review on this topic. A great deal of information can be obtained on the electrical and magnetic nature of these solids, because of the varied response of the thermal conductivity to long range magnetic order,
This comprehensive reference book addresses the unique challenges facing many African nations as poor infrastructure and economics continue to obstruct access to advanced treatments and AIDS care training. It takes into account the context of settings with limited resources. Information on how to best utilize existing resources and prioritize scaling-up of infrastructure is a critical aspect of this book for those working in HIV/AIDS-related fields in Africa.