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Prefoldins: the new chaperones
This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
Cancer and the New Biology of Water
"When President Nixon launched the War on Cancer with the signing of the National Cancer Act of 1971 and the allocation of billions of research dollars, it was amidst a flurry of promises that a cure was within reach. The research establishment was trumpeting the discovery of oncogenes, the genes that supposedly cause cancer. As soon as we identified them and treated cancer patients accordingly, cancer would become a thing of the past. Fifty years later it's clear that the War on Cancer has failed--despite what the cancer industry wants us to believe. New diagnoses have continued to climb; one in three people in the United States can now expect to battle cancer during their lifetime. For the...
EL CÁNCER Y LA NUEVA BIOLOGÍA DEL AGUA
Este libro ofrece una innovadora mirada al papel del agua en los organismos vivos y nos acerca a la respuesta al enigma de la etiología, la terapia y el tratamiento del cáncer. En 1971 el presidente Nixon «declaró» la guerra al cáncer. Inicialmente, la investigación se centró en la genética. Cincuenta años después los diagnósticos siguen al alza y las opciones de tratamiento siguen siendo prácticamente las mismas: cirugía, radiación y quimioterapia. Con tantas vidas en juego, ¿es de extrañar que la gente esté recurriendo cada vez más a los enfoques alternativos? ¿No vale la pena que nos planteemos que podríamos estar buscando en el lugar equivocado? En caso de que valga ...
Las palabras de la ciencia
El término «célula», acuñado en 1665 por Robert Hooke, procede de «celda», el pequeño habitáculo de los monjes. Muchas palabras científicas que hoy creemos fiel reflejo de la esencia de las cosas, en realidad son metáforas que se han fosilizado, que han perdido la viveza de su alumbramiento. Indagar en el origen de cada expresión y sus historias requiere convertirse en una suerte de minero bibliográfico, ávido por encontrar la mena de la fuente primaria para extraer la información más valiosa. El lenguaje científico es un organismo vivo en continua evolución, una manera de aprender a reflexionar, una invitación a explorar misterios, detalles ocultos, esclarecedoras anécdo...
Discover Fossils
Read about fossils, where they are found, and how we learn from them.
Advanced Materials
Advanced materials are the basis of modern science and technology. This proceedings volume presents a broad spectrum of studies of novel materials covering their processing techniques, physics, mechanics, and applications. The book is concentrated on nanostructures, ferroelectric crystals, materials and composites, materials for solar cells and also polymeric composites. Nanotechnology approaches, modern piezoelectric techniques and also latest achievements in materials science, condensed matter physics, mechanics of deformable solids and numerical methods are presented. Great attention is devoted to novel devices with high accuracy, longevity and extended possibilities to work in wide temperature and pressure ranges, aggressive media etc. The characteristics of materials and composites with improved properties opening new possibilities of various physical processes, in particular transmission and receipt of signals under water, are described.
Niacin: The Real Story
This book is for people who want to learn more about niacin and its wonderful healing properties.
Telomeres and Telomerase in Cancer
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Telomeres and Telomerase
Telomeres are essential functional elements of eukaryotic chromosomes. Their fundamental biological role as protectors of chromosome stability was identified for the first time in the 1930s by Hermann Muller and Barbara McClintock based on pioneering cytological experiments. Modern molecular research carried out more recently revealed that telomeres and telomerase play important roles in processes such as carcinogenesis and cellular senescence. This special issue presents the most recent developments in this highly active field of research. It is becoming increasingly clear that molecular pathways involved in regulation of telomere length and structure are functionally linked with pathways involved in DNA damage response, cellular stress response, chromatin organization and perhaps even pathways that regulate evolutionary chromosome rearrangements. The above functional link is explored by the leading experts in the field of telomere biology. Cell biologists, molecular biologists, oncologists, gerontologists, and radiobiologists with an interest in the role of telomeres/telomerase will appreciate the up-to-date information in this publication.
Immunotherapy of Hepatocellular Carcinoma
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. V...
