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Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Updated release includes the latest information on the Neurobiology of Addiction and Co-Morbid Disorders
Proteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were not studied much in the nervous system until the 1990s. The early investigations focused on synaptic plasticity which was followed by studies on the roles of protein degradation in the development of the nervous system. Research on the role of abnormal roles of the UPP follows a parallel trajectory. Since the 2000s, the field has grown to encompass many subareas of research and several model syste...
The place of cannabis in global drug prohibition is in crisis, opening up new directions for socially engaged cannabis research. The Routledge Handbook of Post-Prohibition Cannabis Research invites readers to explore new landscapes of cannabis research under conditions of legalization with, not after, prohibition: "post-prohibition." The chapters are organized into five multidisciplinary sections: Governance, Public Health, Markets and Society, Ecology and the Environment, and Culture and Social Change. Case studies from the United States, Uruguay, Morocco, and the United Kingdom show readers alternative ways of thinking about human–cannabis relationships that move beyond questions of lega...
Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goal...
This volume contains experimental approaches that are currently revolutionizing our understanding of the neurobiology of pain. The chapters cover many cutting-edge methods including the identification of gene expression profiles, transcriptomes or translatomes, from individual cells or defined groups of cells in rodents and primates; the electrophysiological investigation of human tissues, such as human dorsal root ganglion neurons; ways to assess modality response profiles of neurons using calcium imaging in vitro and in vivo; and somatosensory behaviors in rodents using high-speed videography and machine learning. In the Neuromethods series style, the chapters include detailed advice from specialists to obtain successful results in your laboratory. Cutting-edge and comprehensive, Contemporary Approaches to the Study of Pain: From Molecules to Neural Networks is a valuable resource for scientists and researchers interested in making impactful contributions to our understanding of pain.
MICHAEL S. GAZZANIGA The investigation of the human brain and mind involves a myriad of ap proaches. Cognitive neuroscience has grown out of the appreciation that these approaches have common goals that are separate from other goals in the neural sciences. By identifying cognition as the construct of interest, cognitive neuro science limits the scope of investigation to higher mental functions, while simultaneously tackling the greatest complexity of creation, the human mind. The chapters of this collection have their common thread in cognitive neuroscience. They attack the major cognitive processes using functional stud ies in humans. Indeed, functional measures of human sensation, percepti...
Um ihren Bruder zu retten, geht Itomë einen Pakt mit einem uralten, bösen Geist ein. Von den Ihren verbannt, weil sie die uralten Gesetze ihres Clans gebrochen hat, und in einen inneren Kampf mit dem Geist verstrickt, der ihre Seele zu übernehmen versucht, begibt sie sich auf eine Reise ohne Wiederkehr quer durch Ogon. Itomë hat sich eins geschworen: Nie wieder wird sie ihre Entscheidungen von Angst leiten lassen. Von den Flusslanden Nak'Uru zu den fruchtbaren Savannen der Zentauren, von den schneebedeckten Gipfeln Morongos, der Heimat der Dunkelzwerge, zum Reich Massaka, wo die Meister der Magie residieren: »Die Länder von Ogon« sind reich an exotischen Völkern, kraftvollen Mythen und uralten Legenden. Die neue Serie aus dem Fantasy-Universum von Arran erkundet einen faszinierenden neuen Kontinent voller Abenteuer und Exotik.