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Plasticity and Metabolic Switching in Adipose Tissue Macrophages
Macrophages are the most common immune cells present in adipose tissues. These adipose tissue macrophages (ATMs) have an important role in regulating homeostasis and contributing to the metabolically harmful chronic inflammation seen in some obese individuals. Macrophages are cells exhibiting plasticity, that is to alter their polarization between pro- and anti-inflammatory phenotypes, in response to stimuli in their microenvironments. There has been a deal of evidence supporting the heterogeneity of these ATM populations, however, research into their differential functionality, developmental origin, and phenotype warrants further research to reach a consensus. Further questions remain regar...
Penguraian Mekanisme Kerja Bahan Alam Secara In Silico
Bioinformatika telah menjadi kekuatan utama dalam revolusi biologi molekuler dan kedokteran modern, memungkinkan integrasi informasi biologis kompleks seperti sekuensi genetik, struktur protein, dan jalur metabolik. Aplikasi terkemuka dari bioinformatika adalah dalam pencarian obat dari bahan alam. Melalui pendekatan in silico, bioinformatika dapat memprediksi, memodelkan, dan mengoptimalkan senyawa bioaktif dari alam untuk pengembangan obat baru. Buku ini disusun untuk menjelaskan konsep dan langkah-langkah pengembangan obat dari bahan alam secara in silico. Langkah-langkah kerja meliputi penentuan marker ekspresi gen penyakit dari data transkriptomik, identifikasi hub-genes yang bertanggung jawab mengatur jalur persinyalan dan fungsi jaringan, prediksi bioaktivitas senyawa-senyawa dalam bahan alam terhadap perubahan ekspresi gen dan aktivitas protein, serta konfirmasi interaksi senyawa bioaktif dengan protein target menggunakan metode penambatan molekul (molecular docking).
Handbook of Nutrition, Diet, and Epigenetics
This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in whic...
Pediatric Hypertension
The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Brunoy (1). De la fin du duché pairie à la fondation de la République
Cet ouvrage est une réédition numérique d’un livre paru au XXe siècle, désormais indisponible dans son format d’origine.
Imaging of Pulmonary Infections
This book presents a practical approach to the differential diagnosis of pulmonary infections based on their radiographic and CT appearances. The authors discuss the value and limitations of chest radiography, the indications for CT, the optimal CT techniques, and the role of intravenous contrast. Chapters describe and illustrate the characteristic imaging manifestations of common community-acquired and nosocomial pneumonias and various infections seen in immunocompromised patients. The book contains over 400 images and many tables that summarize the characteristic manifestations of bacterial, mycobacterial, fungal, and viral infections. Over 50 full-color illustrations show histopathologic or microbiologic features that correlate with imaging findings.
Oral Antidiabetics
Diabetes continues to spread worldwide. Traditionally diabetes in adults has not been considered a serious life-threatening disease. This attitude needs to be changed, however, since the complications associated with the adult form of diabetes affect almost every organ system. The high morbidity and mortality of Non-Insulin-Dependent Diabetes Mellitus (NIDDM) suggest that current treatment strategies are unsatisfactory, pointing to an urgent need for new therapeutic approaches. This volume provides a comprehensive description and evaluation of recently obtained and previously unpublished data written by leading experts in the field, together with a discussion of antidiabetics under development and new approaches for the management of type 2 diabetes.
