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Advances in RNA-sequencing (RNA-seq) technologies have provided an unprecedented opportunity to explore the gene expression landscape across individuals, tissues, and environments by efficiently profiling the RNA sequences present in the samples. When a reference genome sequence or a transcriptome of the sample is available, mapping-based RNA-seq analysis protocols align the RNA-seq reads to the reference sequences, identify novel transcripts, and quantify the abundance of expressed transcripts.The reads that fail to map to the human reference, known as unmapped reads, are a large and often overlooked output of standard RNA-seq analyses. Even in carefully executed experiments, the unmapped r...
This book constitutes the proceedings of the 23rd Annual Conference on Research in Computational Molecular Biology, RECOMB 2019, held in Washington, DC, USA, in April 2019. The 17 extended and 20 short abstracts presented were carefully reviewed and selected from 175 submissions. The short abstracts are included in the back matter of the volume. The papers report on original research in all areas of computational molecular biology and bioinformatics.
This book constitutes the refereed proceedings of the 11th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2007, held in Oakland, CA, USA in April 2007. The 37 revised full papers address all current issues in algorithmic, theoretical, and experimental bioinformatics.
This book constitutes the proceedings of the 22nd Annual Conference on Research in Computational Molecular Biology, RECOMB 2018, held in Paris, France, in April 2018. The 16 extended and 22 short abstracts presented were carefully reviewed and selected from 193 submissions. The short abstracts are included in the back matter of the volume. They report on original research in all areas of computational molecular biology and bioinformatics.
This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. There are also abstracts from the keynote addresses and invited talks. The papers cover not only theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary appr...
This title includes a number of Open Access chapters.The book introduces bioinformatic and statistical methodology and shows approaches to bias correction and error estimation. It also presents quantitative methods for genome and proteome analysis.
This volume contains the papers presented at RECOMB 2010: the 14th Annual International Conference on Research in Computational Molecular Biology held in Lisbon, Portugal, during April 25–28, 2010. The RECOMB conference series was started in 1997 by Sorin Istrail, Pavel Pevzner, and Michael Waterman. RECOMB 2010 was hosted by INESC-ID and Instituto Superior Tecnico, or- nized by a committee chaired by Arlindo Oliveira and took place at the Int- national Fair of Lisbon Meeting Centre. This year, 36 papers were accepted for presentation out of 176 submissions. The papers presented were selected by the Program Committee (PC) assisted by a number of external reviewers. Each paper was reviewed ...
This book constitutes the refereed proceedings of the 11th International Symposium on Bioinformatics Research and Applications, ISBRA 2015, held in Norfolk, VA, USA, in June 2015. The 34 revised full papers and 14 two-page papers included in this volume were carefully reviewed and selected from 98 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications.
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data prepara...
This book aims to highlight the latest achievements in the use of AI and multimodal artificial intelligence in biomedicine and healthcare. Multimodal AI is a relatively new concept in AI, in which different types of data (e.g. text, image, video, audio, and numerical data) are collected, integrated, and processed through a series of intelligence processing algorithms to improve performance. The edited volume contains selected papers presented at the 2022 Health Intelligence workshop and the associated Data Hackathon/Challenge, co-located with the Thirty-Sixth Association for the Advancement of Artificial Intelligence (AAAI) conference, and presents an overview of the issues, challenges, and potentials in the field, along with new research results. This book provides information for researchers, students, industry professionals, clinicians, and public health agencies interested in the applications of AI and Multimodal AI in public health and medicine.