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In product development, decisions taken in design and manufacturing are considered the most influential factors for succeeding commercialisation. Product development is a complex integrated process of several steps starting from design where the market needs are identified and turned into competitive product specifications and different design concepts. In other words, design is about identifying a problem, developing solution proposals, and validating the most feasible solution with real users. Manufacturing technologies, on the other hand, help designers to make those virtual models into physical parts by transforming different types of raw materials. This book on design and manufacturing, written by a number of experts from all over the world, presents a design perspective and different manufacturing applications from various industrial sectors.
Involvement in work, human interactions, and keen observations teach a lot. What we so learn is meant not merely for saving and application but also for appropriate sharing. Post-retirement Life. free from job responsibilities and work-tension provides an opportunity to relax. to roam, to read. to meditate. to recollect. to introspect. and to mull over mundane happenings. The leisure gives the pleasure of placid pensiveness. And, the thinking, bereft of any ideological or political connectivity enjoys unbridled independence and fairness. With I Pad and Laptop keeping company to lap up my writings, I spent most of my healthy time to key-in my singular experiences and observations and unbiased thoughts and views on varied matters in prose and poetic forms to store in my PC to be retrieved later for publication.
Have you ever been a part of that spectacular moment, which changed your life or the life of someone around you? A moment that was lost in the forgotten lanes of the past? Write Youth brings you a wonderful collection of forgotten stories that ought to be remembered. Life is a mire of uncertainty. The more we struggle, the more we get sucked into it. The beautiful memories along the way amalgamate with the turning tracks of our lives and are sometimes lost forever. We wish to overcome the problems we face in our paths to lead a happy and peaceful life, but destiny has something else planned for us. The best way is to face them head-on with a hope that things will change for the good. Life will then flourish again and the ray of hope will arrive brighter than ever. 'The Forgotten Life' is a leap to bid adieu to hopelessness, to inspire you to meet new people, explore yourself, with positivity and optimism as your guiding powers. We want you to shine again with full enthusiasm and be a glowing flower in the world of wild roses.
This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‐related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.
Publisher Description
Mitochondrial activity is involved in different functions such as cell proliferation, metabolism, Adenosine triphosphate (ATP) generation, and cell death. Particularly, mitochondria play a major role in inflammatory signaling. They regulate the activation, differentiation, and survival of macrophages, while changes in oxidative metabolism alter polarization. Mitochondria are the main source of free radicals, and macrophages increase their oxidative stress levels when they are active. The enhancement of free radicals generation in the mitochondria can damage healthy cells, leading to inflammation. Thus, several diseases associated with an increase in mitochondrial oxidative stress can be asso...
A concise and practical overview of the most important modern synthetic aspects of conjugated polymers and carbon materials, including their properties and applications. Well structured, this book summarizes recent achievements, outlines the current state and reviews research trends. As such, a wide variety of polymerization techniques are included on both a strategic as well as a practical level, including Stille, Suzuki , and direct (hetero)arylation polymerizations. Furthermore, it covers various carbon-rich materials, such as graphene and carbon nanotubes, followed by a look at how the different synthetic pathways and strategies influence their final properties, for example, for use in organic electronic devices. The whole is rounded off with a discussion of future technology advances. An essential reference for newcomers as well as experienced researchers in the field.