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Thymus Transcriptome and Cell Biology
This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.
Biophysical Aspects of Transmembrane Signaling
Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally ...
The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte–TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell develop...
Direct Digital Manufacturing and Polymers
2nd International Conference on Direct Digital Manufacturing and Polymers (2nd CDDMAP) Selected, peer reviewed papers from the 2nd International Conference on Direct Digital Manufacturing and Polymers (2nd CDDMAP), May 15-18, 2017, Marinha Grande, Portugal
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Doubts and Directions in Translation Studies
Like previous collections based on congresses of the European Society of Translation Studies (EST), this volume presents the latest insights and findings in an ever-changing, ever-challenging domain. The twenty-six papers, carefully chosen from about 140 presented at the 4th EST Congress, offer a bird's eye view of the most pressing concerns and most exciting vistas in Translation Studies today. The editors' final choices reflect a focus on quality of approach, originality of topic, and clarity of presentation, and aim at capturing the most salient developments in the contemporary theory, methodology and technology of TS. As always in EST, the themes covered relate to translation as well as interpreting. They include discussion of a broad range of text-types and skopoi, and a diversity of themes, such as translation universals, translation strategies, translation and ideology, perception of translated humor, translation tools, etc. Many of the papers force us to take a fresh look at seemingly well established paradigms and familiar notions, while also making recourse to work being done in other disciplines (Semiotics, Linguistics, Discourse Analysis, Contrastive Studies).
Biomaterials from Nature for Advanced Devices and Therapies
In-depth information on natural biomaterials and their applications for translational medicine! Undiluted expertise: edited by world-leading experts with contributions from top-notch international scientists, collating experience and cutting-edge knowledge on natural biomaterials from all over the world A must-have on the shelf in every biomaterials lab: graduate and PhD students beginning their career in biomaterials science and experienced researchers and practitioners alike will turn to this comprehensive reference in their daily work Link to clinical practice: chapters on translational research make readers aware of what needs to be considered when a biomaterial leaves the lab to be routinely used
