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Meningitis is an uncommon but serious illness at any age, and during the first few weeks of life it poses a particular hazard with high mortality and a considerable risk to survivors of permanent damage to the developing brain. This book comprehensively reviews bacterial, fungal and viral forms of the illness. Epidemiology and comparisons of maternally and environmentally derived infections are included, along with a view of the developing brain and host defence mechanisms. A review of experimental bacterial meningitis is provided, together with a discussion of its relevance for clinical and laboratory diagnosis, and for antimicrobial and supportive management. Prospects for the future in terms of early diagnosis, management and prevention are also addressed. In its collation of material from such a wide range of literature sources, this is a vital reference for all clinicians with an interest in the problems of meningitis in early life.
An inflammation of the brain or membranes of the nervous system, meningitis is a potentially deadly disease that comes in two main forms: one caused by a virus and one caused by a bacteria.
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Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.