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Angiogenesis & Therapeutic Targets in Cancer
Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on c
Multiple Myeloma - A New Era of Treatment Strategies
"Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced"
Neither Good Nor Bad
When confronted by a range of violent actions perpetrated by lone individuals, contemporary society exhibits a constant tendency to react in terms of helpless, even perplexed horror. Seeking explanations for the apparently inexplicable, commentators often hurry to declare the perpetrators as “evil”. This question is not restricted to individuals: history has repeatedly demonstrated how groups and even entire nations can embark on a criminal plan united by the conviction that they were fighting for a good and just cause. Which circumstances occasioned such actions? What was their motivation? Applying a number of historical, scientific and social-scientific approaches to this question, this study produces an integrative portrait of the reasons for human behavior and advances a number of different interpretations for their genesis. The book makes clear the extent to which we live in socially-constructed realities in which we cling for dear life to a range of conceptions and beliefs which can all too easily fall apart in situations of crisis.
Plasma Cell Dyscrasias
This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.
The Pre-existing T Cell Landscape Determines the Response to Bispecific T Cell Engagers in Multiple Myeloma Patients
Abstract: Bispecific T cell engagers (TCEs) have shown promise in the treatment of various cancers, but the immunological mechanism and molecular determinants of primary and acquired resistance to TCEs remain poorly understood. Here, we identify conserved behaviors of bone marrow-residing T cells in multiple myeloma patients undergoing BCMAxCD3 TCE therapy. We show that the immune repertoire reacts to TCE therapy with cell state-dependent clonal expansion and find evidence supporting the coupling of tumor recognition via major histocompatibility complex class I (MHC class I), exhaustion, and clinical response. We find the abundance of exhausted-like CD8+ T cell clones to be associated with clinical response failure, and we describe loss of target epitope and MHC class I as tumor-intrinsic adaptations to TCEs. These findings advance our understanding of the in vivo mechanism of TCE treatment in humans and provide the rationale for predictive immune-monitoring and conditioning of the immune repertoire to guide future immunotherapy in hematological malignancies
Handbook of Ontologies for Business Interaction
"This book documents high-quality research addressing ontological issues relevant to the modeling of enterprises and information systems in general, and business processes in particular covering both static and dynamic aspects of structural concepts. It provides reference content to researchers, practitioners, and scholars in the fields of language design, information systems, enterprise modeling, artificial intelligence, and the Semantic Web"--Provided by publisher.
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Neri Oxman: Material Ecology
Throughout her 20-year career, Neri Oxman has invented not only new ideas for materials, buildings and construction processes, but also new frameworks for interdisciplinary?and interspecies?collaborations. She coined the term ?material ecology? to describe her process of producing techniques and objects informed by the structural, systemic and aesthetic wisdom of nature. Groundbreaking for its solid technological and scientific basis, its rigorous and daring experimentation, its visionary philosophy and its unquestionable attention to formal elegance, Oxman?s work operates at the intersection of biology, engineering, architecture and artistic design, material science and computer science.0Th...
