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Fluorescent Proteins
This new edition of Fluorescent Proteins presents current applications of autofluorescent proteins in cell and molecular biology authored by researchers from many of the key laboratories in the field. Starting from a current review of the broad palette of fluorescent proteins available, several chapters focus on key autofluorescent protein variants, including spectral variants, photodynamic variants as well as chimeric FP approaches. Molecular applications are addressed in chapters that detail work with single molecules, approaches to generating protein fusions and biosensors as well as analysis of protein-protein interactions in vivo by FRET, fluorescence polarization and fluorescence cross...
Telomerases
This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.
Human Placental Trophoblasts
Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critic
RNA-Ligand Interactions, Part B: Molecular Biology Methods
RNA-Ligand Interactions, Part B focuses on molecular biology methods. Major topics covered include: solution probe methods, tethered-probe methodologies, in vitro affinity selection methodologies, genetic methodologies for detecting RNA-protein interactions, protein engineering methodologies useful for RNA-protein interaction studies, and cell biology methods.RNA-Ligand Interactions, Part A, its companion, VOLUME 317 focuses on structural biology methods.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Recoding: Expansion of Decoding Rules Enriches Gene Expression
The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solv...
Aging, Cancer and Age-related Disease
"This volume presents manuscripts stemming from the 13th Congress of the International Association of Biomedical Gerontology entitled 'Aging, Cancer, and Age-Related Diseases: common Mechanisms?' held on May 18-20, 2009 in Quebec City, Quebec, Canada"--P. [iii].
RNA Structure and Function
The striking functional versatility of RNA is attributable to its remarkable capacity for conformational change. Current models of RNA synthesis, its maturation, translation and degradation are all based on specific structures and there is growing appreciation of the functional importance of interactions between RNA and RNA-binding proteins. This work identifies the major intellectual and technical advances in understanding the part played by structure in how RNA works. It encompasses the experimental approaches used to define RNA structure and its influence on RNA functions such as transcription termination, catalysis, recoding and translational control. Investigators with these interests and students of molecular biology should find this volume a provocative survey of a rapidly-advancing field and a valuable complement to the monograph, The RNA World.
