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Twenty-year Trends in Prostate Cancer Stage and Grade Migration in a Large Contemporary German Radical Prostatectomy Cohort
Background: A trend towards inverse stage migration in prostate cancer (PCa) was reported. However, previous analyses did not take into account potential differences in sampling strategies (number of biopsy cores), which might have confounded these reports. Material and Methods: Within our single-institutional database we identified PCa patients treated with radical prostatectomy (RP) between 2000 and 2020 (n)=)21,646). We calculated the estimated annual percentage change (EAPC) for D'Amico risk groups, biopsy Gleason Grade Group (GGG), PSA and cT stage as well as postoperative RP GGG and pT stage relying on log linear regression methodology. Subsequently, we repeated the analyses after adjustment for number of cores obtained at biopsy. Results: Absolute rates of D'Amico low risk decreased (-30.1%), while intermediate and high risk increased (+21.2% and +9.0%, respectively). Rates of GGG I decreased (-50.0%), while GGG II-V increased, with the largest increase in GGG II (+22.5%). This trend, albeit less pronounced, was also recorded after adjusted EAPC analyses (p)
Holmium Laser Enucleation of the Prostate: Efficacy, Safety and Preoperative Management in Patients Presenting with Anticoagulation Therapy
Purpose: We evaluated efficacy and safety profile of patients with anticoagulation therapy (AT) undergoing holmium laser enucleation of the prostate (HoLEP). Methods: Within our prospective institutional database (11/2017 to 11/2019), we analyzed functional outcomes and 30-day complication rates of HoLEP patients according to Clavien-Dindo classification (CLD), stratified according to specific AT vs. no AT. Further analyses consisted of uni- and multivariate logistic regression models (LRM) predicting complications. Results: Of 268 patients undergoing HoLEP, 104 (38.8%) received AT: 25.7% were treated with platelet aggregation inhibitors (PAI), 8.2% with new oral anticoagulants (NOAC) and 4.9% with AT-combinations or coumarins bridged with low molecular weight heparins (LMWH/combination). Patients receiving AT were significantly more comorbid (p)
Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
A Journey of Faith Across a Turbulent Century
How do you find the courage to go on when everything you knew is gone? That is a question faced by Philipp Weingartner several times in his life. Born into a family of insignificant farm labourers in a town, region, and country erased from our maps, Philipp set out on a journey—both geographical and spiritual—across the front lines of two World Wars, and eventually across an ocean to a new life in Canada. This biographic collaboration between Erich Weingartner and his late father Philipp's writings gives witness to the tenacity of the human spirit. It provides abundant affirmation that commitment to a life of faith can empower ordinary people to become extraordinary in times of great need. Based on diaries, letters, articles and sermons, A Journey of Faith details one man's lived experience of tragedy, survival, and a passion to serve the less fortunate.
Optical Detectors for Astronomy
The Workshop "Optical Detectors for Astronomy" was held during October 8-10, 1996 at the headquarters of the European Southern Observatory in Garching, Germany. This was the third meeting of its kind, previous meetings being held in 1991 and 1993, but this is the first ESO "CCD Workshop" that has published proceedings. Most of the leading manufacturers and major astronomical observatories were represented, with the 117 attendees coming together from 14 different countries that spanned every continent on Earth. The motivation for the ESO CCD Workshop series is the creation of informal and open venue of information exchange about astronomical CCD detectors and systems. Judging from the reactio...
