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Deciphering the T Cell Response in SARS-CoV-2 Infection
COVID-19 is a recently emerged infectious disease caused by the novel coronavirus SARS-CoV-2. The immune system has a primary role in pathogen elimination and a rapid and effective response can limit disease severity. In this context, T cells play the major role in cell mediated adaptive immune response. The protective role of CD4+ and CD8+ T cells has been inferred from studies on patients who recovered from SARS and MERS and accumulating data are now showing their relevance in SARS-CoV-2 infection. Moreover, memory T cells induced by previous pathogens can shape the susceptibility to, and the clinical severity of other infections, but the complete picture has yet to be elucidated. If the virus is not rapidly eliminated, COVID-19 may progress towards a secondary inflammatory phase that is directly responsible for a worsening in clinical symptoms and immune system impairment. Besides marked lymphopenia, COVID-19 patients’ T cell compartment displays several alterations involving different subpopulations of T cells in terms of phenotype, metabolic profile and functionality.
Computational Science and Technology
This book gathers the proceedings of the Seventh International Conference on Computational Science and Technology 2020 (ICCST 2020), held in Pattaya, Thailand, on 29–30 August 2020. The respective contributions offer practitioners and researchers a range of new computational techniques and solutions, identify emerging issues, and outline future research directions, while also showing them how to apply the latest large-scale, high-performance computational methods.
IMUNOLOGI DASAR
Buku ini membahas tentang imunologi dengan lebih rinci dan mendalam sesuai dengan pengetahuan yang dibutuhkan dalam imunologi dasar. Pembahasan dalam tiap bab dan sub bab dirancang secara jelas dan memperhatikan perkembangan dalam imunologi namun tidak terlalu panjang. Referensi yang digunakan adalah referensi-referensi yang mutakhir sehingga banyak hal baru yang bisa dilihat pada buku ini. Referensi lama kami gunakan jika tidak ditemukan referensi yang berumur kurang dari lima tahun dan hasil penelitian pada referensi tersebut masih relevan dengan imunologi masa kini. Di dalam buku ini juga memuat bab khusus yang membahas integrasi imunologi dengan ajaran islam. Kesemua hal tersebut menurut hemat kami merupakan sisi baik dari buku ini.
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NETosis: At the Intersection of Cell Biology, Microbiology, and Immunology
NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflamma...
Robot Design Handbook, Robocon Malaysia, 2019 (IIUM PRESS)
This book compiles technical design notes from the teams that have participated in ROBOCON Malaysia 2019. Every chapter details how the team design their robots to achieve the mission specified in ROBOCON Malaysia 2019 rules. Every report consists of three sub-topics: mechanical design, electronics circuit design and programming. The reports presented in this collection are written in English. The purpose of this book is to share and pass on the valuable knowledge of engineering and robotics to other robotic enthusiasts especially in Malaysia. This book would be the first in the series to set the trend of knowledge sharing from the ROBOCON Malaysia. We hope this book series would be a reference for future robotics competition and robotics enthusiasts with the aim of being able to develop more advance robotics system by learning from the experiences of others.
Affordable Excellence
"Today Singapore ranks sixth in the world in healthcare outcomes well ahead of many developed countries, including the United States. The results are all the more significant as Singapore spends less on healthcare than any other high-income country, both as measured by fraction of the Gross Domestic Product spent on health and by costs per person. Singapore achieves these results at less than one-fourth the cost of healthcare in the United States and about half that of Western European countries. Government leaders, presidents and prime ministers, finance ministers and ministers of health, policymakers in congress and parliament, public health officials responsible for healthcare systems planning, finance and operations, as well as those working on healthcare issues in universities and think-tanks should know how this system works to achieve affordable excellence."--Publisher's website.
