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Integrative Omics
Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identi...
Genomics of Plant–Pathogen Interaction and the Stress Response
Plants are an indispensable part of human and animal lives for nutrition and health. But pests, diseases and abiotic stress adversely affect crop yield, which ultimately places significant pressure on society to provide food to an increasing population. Moreover, it also encourages increased chemical/pesticide usage on crops, which we see in the biomagnification of toxic and hazardous compounds polluting water bodies, soil and the environment. This condition will continue to worsen in the future due to the resistance-acquiring ability of pathogens against plant defense and chemical treatments. In addition, environmental disturbances and consumer health issues are being reported more promptly...
Computer-Aided Drug Design
This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
Recent Trends in 'Computational Omics: Concepts and Methodology'
The last decade has witnessed various technological advances in life sciences, especially high throughput technologies. These technologies provide a way to perform parallel scientific studies in a very short period of time with low cost. High throughput techniques, mainly, next generation sequencing, microarray and mass spectrometry, have strengthened the omics vision in the last decades (study of complete system) and now resulted in well-developed branches of omics i.e., genomics, transcriptomics, proteomics and metabolomics, which deal with almost every level of central dogma of life. Practice of high throughput techniques throughout the world with different aims and objectives resulted in...
Enzymes in the Valorization of Waste
Enzymes in the Valorization of Waste: Next-Gen Technological Advances for Sustainable Development of Enzyme-based Biorefinery focusses on key enzymes which are involved in the development of integrated biorefinery. It highlights the modern next-gen technologies for promoting the application of sustainable and greener enzymatic steps at industrial scale for the development of futuristic and self-sustainable "consolidated/integrated biorefinery/enzyme-based biorefinery." It also deals with technological advancement for improvement of enzyme yield or specificity, conversion capability, such as protein and metabolic engineering and advances in next generation technologies, and so forth. Features...
Recent Advances in Computer Aided Drug Designing
We are extremely happy to introduce our new book, Recent Advances in Computer Aided Drug Designing. While interacting with many researchers in the field of biotechnology and allied sciences, we felt that there was need for a book that could easily bridge the gap between in silico methods applied in structural bioinformatics for drug designing and wet lab workers. Today, when computational skills in biology and biomedical research are in high demand, this book presents updated content for methods and tools applicable in modern computer-aided drug designing. Researchers are pouring knowledge into databases that are publicly available and laboratories across the globe are accessing this informa...
Pharmacogenomics in Drug Discovery and Development
This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.
Readings in the Shed
Readings in the shed completed three years of performing stories on 23rd April 2021. Under normal circumstances the celebrations would involve theatrical performances of birthday stories. Actors would perform, and audiences would fill the seats. The pandemic and the restrictions that accompany it, stopped the stories from making it to the stage. But stories travel, in one form or another. Thus, they took the form of a book that might quietly travel and reach the stage of the reader’s mind where the performances may continue. The stories in this anthology are varied in theme, setting and concept. Nikhil Katara’s Pride, set in the wild narrates the story of an aging lion. While his O2 explores the implication of choices especially in difficult times. Himali Kothari’s Coming of Age is the story of Pushpa who has lived her life in the hope that her birth may have been of value. The Birthday Stories is a story of friendship and acceptance.
Stem Cells from Culture Dish to Clinic
Despite extensive research and medical advancements in the prevention, diagnosis and treatment of dreaded diseases like Diabetes, Cancer, Neurodegenerative and Heart diseases, continue to impose a great threat to human life. Research in human developmental biology has led to the discovery of stem cells which has the potential to cure wide range of dreaded diseases. Stem cells are the unicellular equivalent to the entire animal. In optimum culture milieu they can be differentiated into all cell types of an adult animal. The capability of potency and the relative ease to isolate and expand these cells are invaluable properties for regenerative medicine. Stem cells hold tremendous promise to un...
